1.Application of absorbable anchor combined with Kirschner wire in reconstruction of extension function of old mallet finger.
Dongdong CHENG ; Zhengbing ZHOU ; Zixuan LIN ; Hui LIU ; Fan YANG ; Jin WANG ; Shang GUO
Chinese Journal of Reparative and Reconstructive Surgery 2023;37(4):443-446
		                        		
		                        			OBJECTIVE:
		                        			To investigate the feasibility and effectiveness of absorbable anchor combined with Kirschner wire fixation in the reconstruction of extension function of old mallet finger.
		                        		
		                        			METHODS:
		                        			Between January 2020 and January 2022, 23 cases of old mallet fingers were treated. There were 17 males and 6 females with an average age of 42 years (range, 18-70 years). The cause of injury included sports impact injury in 12 cases, sprain in 9 cases, and previous cut injury in 2 cases. The affected finger included index finger in 4 cases, middle finger in 5 cases, ring finger in 9 cases, and little finger in 5 cases. There were 18 patients of tendinous mallet fingers (Doyle type Ⅰ), 5 patients were only small bone fragments avulsion (Wehbe type ⅠA). The time from injury to operation was 45-120 days, with an average of 67 days. The patients were treated with Kirschner wire to fix the distal interphalangeal joint in a mild back extension position after joint release. The insertion of extensor tendon was reconstructed and fixed with absorbable anchors. After 6 weeks, the Kirschner wire was removed, and the patients started joint flexion and extension training.
		                        		
		                        			RESULTS:
		                        			The postoperative follow-up ranged from 4 to 24 months (mean, 9 months). The wounds healed by first intention without complications such as skin necrosis, wound infection, and nail deformity. The distal interphalangeal joint was not stiff, the joint space was good, and there was no complication such as pain and osteoarthritis. At last follow-up, according to Crawford function evaluation standard, 12 cases were excellent, 9 cases were good, 2 cases were fair, and the good and excellent rate was 91.3%.
		                        		
		                        			CONCLUSION
		                        			Absorbable anchor combined with Kirschner wire fixation can be used to reconstruct the extension function of old mallet finger, which has the advantages of simple operation and less complications.
		                        		
		                        		
		                        		
		                        			Male
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Bone Wires
		                        			;
		                        		
		                        			Fracture Fixation, Internal
		                        			;
		                        		
		                        			Finger Injuries/surgery*
		                        			;
		                        		
		                        			Fractures, Bone/surgery*
		                        			;
		                        		
		                        			Tendon Injuries/surgery*
		                        			;
		                        		
		                        			Fingers
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Finger Joint/surgery*
		                        			
		                        		
		                        	
2.Diagnosis and treatment of finger flexion contracture caused by forearm flexor disease.
Peng TANG ; Jianwei WEI ; Zhonggen DONG ; Lihong LIU ; Ao SHEN ; Jianhua WANG
Chinese Journal of Reparative and Reconstructive Surgery 2023;37(4):447-451
		                        		
		                        			OBJECTIVE:
		                        			To summarize the clinical characteristics, differential diagnosis, and treatment methods of finger flexion contracture caused by three kinds of forearm flexor diseases.
		                        		
		                        			METHODS:
		                        			Between December 2008 and August 2021, 17 patients with finger flexion contracture were treated, including 8 males and 9 females, aged 5-42 years, with a median of 16 years. The disease duration ranged from 1.5 months to 30 years, with a median of 13 years. The etiology included 6 cases of Volkmann's contracture, all of which were flexion deformity of the 2nd to 5th fingers, accompanied by limitation of thumb dorsiflexion in 3 cases and limitation of wrist dorsiflexion in 3 cases; 3 cases of pseudo-Volkmann's contracture, including 2 cases of flexion deformity of middle, ring, and little fingers, and 1 case of flexion deformity of ring and little fingers; 8 cases of ulnar finger flexion contracture caused by forearm flexor disease or anatomical variations, all of which were flexion deformity of middle, ring, and little fingers. Operations such as slide of flexor and pronator teres origin, excision of abnormal fibrous cord and bony prominence, and release of entrapped muscle (tendon) were performed. Hand function was evaluated according to WANG Haihua's hand function rating standard or modified Buck-Gramcko classification standard, and muscle strength was evaluated according to British Medical Research Council (MRC) muscle strength rating standard.
		                        		
		                        			RESULTS:
		                        			All patients were followed up 1-10 years (median, 1.5 years). At last follow-up, 8 patients with contracture caused by forearm flexor disease or anatomical variations and 3 patients with pseudo-Volkmann's contracture achieved excellent hand function, with muscle strength of grade M5 in 6 cases and grade M4 in 5 cases. One patient with mild Volkmann's contracture and 3 patients with moderate Volkmann's contracture without severe nerve damage had excellent hand function in 2 cases and good in 2 cases, with muscle strength of grade M5 in 1 case and grade M4 in 3 cases. Two patients with moderate or severe Volkmann's contracture had poor hand function, with 1 case of muscle strength of grade M3 and 1 case of grade M2, which improved when compared with those before operation. The overall excellent and good rate of hand function and the proportion of patients with muscle strength of grade M4 and above were 88.2% (15/17), respectively.
		                        		
		                        			CONCLUSION
		                        			The finger flexion contracture caused by different etiology can be differentiated by analyzing the history, physical examination, radiographs, and intraoperative findings. After different surgical treatments, such as resection of contracture band, release of compressed muscle (tendon), and downward movement of flexor origin, most patients have a good outcome.
		                        		
		                        		
		                        		
		                        			Male
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Forearm/surgery*
		                        			;
		                        		
		                        			Contracture/surgery*
		                        			;
		                        		
		                        			Ischemic Contracture/surgery*
		                        			;
		                        		
		                        			Fingers/surgery*
		                        			;
		                        		
		                        			Muscle, Skeletal/surgery*
		                        			
		                        		
		                        	
3.A V-Y shaped flap with digital artery nerve at metacarpophalangeal joint was used to repair the defect of middle and distal phalanx.
Ji-Chao HU ; Jian HE ; Jun-Bo CHEN ; Kai-Dong BU
China Journal of Orthopaedics and Traumatology 2023;36(6):564-569
		                        		
		                        			OBJECTIVE:
		                        			To explore a surgical method for the reconstruction of volar soft tissue defect and sensory and vascular repair in middle and far phalangeal digits.
		                        		
		                        			METHODS:
		                        			From January 2016 to January 2020, a total of 14 patients , 9 males and 5 females, ages ranging from 22 to 69 years old, and with volar soft tissue defects in the middle and distal digits 2 to 4, underwent surgical reconstruction using the V-Y shaped flap with digital artery and nerve at the metacarpophalangeal joint. The defect area was (2.0~2.5) cm×(1.5 ~2.0) cm. The procedure involved the harvest of a V-Y shaped flap with the digital artery and nerve from the metacarpophalangeal joint. Flap design, dissection of blood vessels and nerves, and anastomosis with the digital artery and nerve were performed according to a standardized protocol., Functional exercise of affected finger was initiated 3 weeks postoperatively. Subsequent assessments were conducted to evaluate finger pulp sensation, shape and other relevant parameters. According to the upper extremity functional evaluation standard set up by Hand Surgery Branch of Chinese Medical Association, the surgical outcomes were evaluated.
		                        		
		                        			RESULTS:
		                        			All 14 cases demonstrated successful tissue transplantation, , with immediate recovery of sensation observed in 10 cases with distal finger pulp defects. Four patients with middle phalangeal defects experienced gradual sensory recovery within 2 to 3 months postoperatively. Thirteen patients were followed up for a mean duration of (8.8 ± 4.49) months, during which satisfactory outcomes were observed. The average two-point resolution of the finger pulp was 4-6mm, and sensory function evaluation yielded a score of S3 or above. Patients exhibited realistic finger shape, normal skin color and temperature, good wear resistance, and cold resistance. Furthermore, finger joint function was essentially normal.
		                        		
		                        			CONCLUSION
		                        			The V-Y shaped flap with digital artery and nerve at the metacarpophalangeal joint offers a suitable solution for repairing the defect of the middle or distal phalangeal finger. This technique is characterized by its simplicity, low risk, and favorable outcomes, including restored finger shape, blood supply and sensation. Moreover, high patient satisfaction was achieved.
		                        		
		                        		
		                        		
		                        			Male
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Young Adult
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Plastic Surgery Procedures
		                        			;
		                        		
		                        			Skin Transplantation
		                        			;
		                        		
		                        			Finger Injuries/surgery*
		                        			;
		                        		
		                        			Treatment Outcome
		                        			;
		                        		
		                        			Soft Tissue Injuries/surgery*
		                        			;
		                        		
		                        			Fingers/surgery*
		                        			;
		                        		
		                        			Ulnar Artery/surgery*
		                        			;
		                        		
		                        			Metacarpophalangeal Joint/surgery*
		                        			
		                        		
		                        	
4.Clinical and genetic analysis of a child with Culler-Jones syndrome due to variant of GLI2 gene.
Yanshi FAN ; Shuxia DING ; Junhua WU ; Haiyan QIU
Chinese Journal of Medical Genetics 2023;40(2):217-221
		                        		
		                        			OBJECTIVE:
		                        			To explore the genetic basis for a child featuring short stature and postaxial polydactyly.
		                        		
		                        			METHODS:
		                        			A child who presented at Ningbo Women & Children's Hospital in May 2021 due to the"discovery of growth retardation for more than two years" was selected as the subject. Peripheral blood samples of the child and his parents were collected for the extraction of genomic DNA. Whole exome sequencing was carried out for the child, and candidate variant was verified by Sanger sequencing of his family members.
		                        		
		                        			RESULTS:
		                        			The child was found to harbor a heterozygous c.3670C>T (p.Q1224) variant of the GLI2 gene, which may lead to premature termination of protein translation. The variant was not detected in either parent.
		                        		
		                        			CONCLUSION
		                        			The child was diagnosed with Culler-Jones syndrome. The c.3670C>T (p.Q1224*) variant of the GLI2 gene probably underlay the disease in this child.
		                        		
		                        		
		                        		
		                        			Child
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Fingers
		                        			;
		                        		
		                        			Mutation
		                        			;
		                        		
		                        			Nuclear Proteins/genetics*
		                        			;
		                        		
		                        			Polydactyly/genetics*
		                        			;
		                        		
		                        			Toes
		                        			;
		                        		
		                        			Zinc Finger Protein Gli2/genetics*
		                        			
		                        		
		                        	
5.Effectiveness of dorsal perforator flap of cross-finger proper digital artery in treatment of high-pressure injection injuries of the finger.
Wei ZHANG ; Gaofeng LIANG ; Manying ZHANG ; Zhongyu JIA ; Zonghai JIA ; Junwen DONG ; Chaopeng DUAN ; Feng ZHI ; Yunsheng TENG ; Yongming GUO
Chinese Journal of Reparative and Reconstructive Surgery 2023;37(9):1138-1141
		                        		
		                        			OBJECTIVE:
		                        			To investigate the effectiveness of dorsal perforator flap of cross-finger proper digital artery in the treatment of finger soft tissue defect caused by high-pressure injection injury.
		                        		
		                        			METHODS:
		                        			Between July 2011 and June 2020, 14 cases of finger soft tissue defect caused by high-pressure injection injury were repaired with dorsal perforator flap of cross-finger proper digital artery. All patients were male, with a mean age of 36 years (range, 22-56 years). The defects were located on the index finger in 8 cases, middle finger in 4 cases, and ring finger in 2 cases. The causes of injury include 8 cases of emulsion paint injection, 4 cases of oil paint injection, and 2 cases of cement injection. The time from injury to debridement was 2-8 hours, with a mean time of 4.5 hours. The soft tissue defects sized from 4.0 cm×1.2 cm to 6.0 cm×2.0 cm. The flaps sized from 4.5 cm×1.5 cm to 6.5 cm×2.5 cm. The donor site of the flap was repaired with skin graft. The pedicle was cut off at 3 weeks after operation, and followed by functional exercise.
		                        		
		                        			RESULTS:
		                        			All flaps and skin grafts at donor sites survived, and the wounds healed by first intention. Twelve patients were followed-up 16-38 months (mean, 22.6 months). The texture and appearance of all flaps were satisfactory. The color and texture of the flaps were similar to those of the surrounding tissues. The two-point discrimination of the flap was 10-12 mm, with a mean of 11.5 mm. There were different degrees of cold intolerance at the end of the affected fingers. At last follow-up, the finger function was evaluated according to the Upper Extremity Functional Evaluation Standard set up by Hand Surgery Branch of Chinese Medical Association, 3 cases were excellent, 8 cases were good, and 1 case was poor.
		                        		
		                        			CONCLUSION
		                        			The dorsal perforator flap of cross-finger proper digital artery can effectively repair finger soft tissue defect caused by high-pressure injection injury. The operation was simple, and the appearance and function of the finger recover well.
		                        		
		                        		
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Perforator Flap
		                        			;
		                        		
		                        			Upper Extremity
		                        			;
		                        		
		                        			Fingers/surgery*
		                        			;
		                        		
		                        			Ulnar Artery
		                        			;
		                        		
		                        			Skin Transplantation
		                        			
		                        		
		                        	
6.Free posterior interosseous artery perforator flap in the treatment of finger with skin and soft tissue defect.
Qiong WU ; Ji-Yong JIANG ; Jiang-Lai FAN ; De-Yu ZHANG ; Jin-Yu WANG
China Journal of Orthopaedics and Traumatology 2023;36(8):714-718
		                        		
		                        			OBJECTIVE:
		                        			To explore clinical effects of repairing skin and soft tissue defect of finger with free posterior interosseous artery perforator flap.
		                        		
		                        			METHODS:
		                        			Totally 8 patients with finger skin and soft tissue defect repaired with free posterior interosseous artery perforator flap were treated from May 2021 to November 2022, including 7 males and 1 female aged from 24 to 54 years old, and soft tissue defect area ranged from 3.0 cm×1.5 cm to 5.0 cm×3.0 cm. The time from injury to flap repair ranged from 3 to 83 h. The free posterior interosseous artery perforator flap was applied to repair finger defect, the area of the flap ranged from 3.5 cm×2.0 cm to 5.2 cm×3.5 cm, the donor area of flap was sutured directly. The survival, appearance, texture and donor complications of the flap were observed after operation, and Dargan functional standard was used to evaluate clinical effect of finger function.
		                        		
		                        			RESULTS:
		                        			All flap of 8 patients were survived, and followed up from 3 to 12 months. There was no obvious swelling, soft texture, obvious pigmentation, linear intaglio in donor area only, and without obvious complications were found. Among them, 3 patients'skin flaps were repaired for the defect of palm of the fingers, and sensory recovery was good, two-point discrimination ranged from 5 to 9 mm. According to Dargan functional evaluation, 3 patients excellent, and 5 good.
		                        		
		                        			CONCLUSION
		                        			Free posterior interosseous artery perforation branch flap could be used to repair the defect of finger. The thickness of flap is moderate, operation is convenient, appearance and texture of the operative flap are good, and the donor site is small without obvious complications, and obtain satisfactory clinical effect.
		                        		
		                        		
		                        		
		                        			Male
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Young Adult
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Perforator Flap
		                        			;
		                        		
		                        			Fingers
		                        			;
		                        		
		                        			Upper Extremity
		                        			;
		                        		
		                        			Ulnar Artery
		                        			;
		                        		
		                        			Skin
		                        			
		                        		
		                        	
7.One-stage repair of full-thickness skin defect at dorsal skin of middle phalanx fingers using artificial dermis combing with digital artery perforator fascial flaps.
Ke-Jie WANG ; Xiao-Feng TENG ; Ke-Yue YANG ; Jian RUAN
China Journal of Orthopaedics and Traumatology 2023;36(8):719-723
		                        		
		                        			OBJECTIVE:
		                        			To explore clinical effects of the stageⅠrepair of full-thickness skin defect at dorsal skin of middle phalanx fingers using artificial dermis combing with digital artery perforator fascial flaps.
		                        		
		                        			METHODS:
		                        			From January 2019 to May 2020, 21 patients(27 middle phalanx fingers)with full-thickness skin defect were repaired at stageⅠusing artificial dermis combing with digital artery perforator fascial flaps. All patients were emergency cases, and were accompanied by the exposure of bone tendon and the defects of periosteum and tendon membrane. Among patients, including 11 males and 10 females aged from 18 to 66 years old with an average age of (39.00±8.01) years old;9 index fingers, 10 middle fingers and 8 ring fingers;range of skin defect area ranged from (2.5 to 3.5) cm×(1.5 to 3.0) cm;range of exposed bone tendon area was (1.5 to 2.0) cm×(1.0 to 2.0) cm. The time from admission to hospital ranged from 1 to 6 h, operation time started from 3 to 8 h after injury.
		                        		
		                        			RESULTS:
		                        			All patients were followed up from 6 to12 months with an average of (9.66±1.05) months. The wounds in 26 cases were completely healed at 4 to 6 weeks after operation. One finger has changed into wound infection with incompletely epithelialized dermis, and achieved wound healing at 8 weeks after dressing change. All fingers were plump with less scars. The healed wound surface was similar to the color and texture of the surrounding skin. These fingers have excellent wearability and flexibility. According to the upper limb function trial evaluation standard of Hand Surgery Society of Chinese Medical Association, the total score ranged from 72 to 100. 26 fingers got excellent result and 1 good.
		                        		
		                        			CONCLUSION
		                        			StageⅠrepair of full-thickness skin defect at dorsal skin of middle phalanx fingers using artificial dermis combing with digital artery perforator fascial flaps is easy to operate with less trauma. It has made satisfactory recovery of appearance and function of fingers. It could provide an effective surgical method for clinical treatment of full-thickness skin loss of fingers with tendon and bone exposure.
		                        		
		                        		
		                        		
		                        			Female
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Young Adult
		                        			;
		                        		
		                        			Aged
		                        			;
		                        		
		                        			Fingers
		                        			;
		                        		
		                        			Skin
		                        			;
		                        		
		                        			Perforator Flap
		                        			;
		                        		
		                        			Ulnar Artery
		                        			;
		                        		
		                        			Dermis
		                        			
		                        		
		                        	
8.Angiodynamic and optical coupling analysis of skin tissue model under finite pressure.
Hetong ZHAO ; Liang ZHOU ; Zhaohui LIU ; Wenlong QIAO ; Xiaoxiao SUN ; Le JIANG ; Yuanyuan LYU
Journal of Biomedical Engineering 2022;39(3):527-536
		                        		
		                        			
		                        			The pulse amplitude of fingertip volume could be improved by selecting the vascular dense area and applying appropriate pressure above it. In view of this phenomenon, this paper used Comsol Multiphysics 5.6 (Comsol, Sweden), the finite element analysis software of multi-physical field coupling simulation, to establish the vascular tissue model of a single small artery in fingertips for simulation. Three dimensional Navier-Stokes equations were solved by finite element method, the velocity field and pressure distribution of blood were calculated, and the deformation of blood vessels and surrounding tissues was analyzed. Based on Lambert Beer's Law, the influence of the longitudinal compression displacement of the lateral light surface region and the tissue model on the light intensity signal is investigated. The results show that the light intensity signal amplitude could be increased and its peak value could be reduced by selecting the area with dense blood vessels. Applying deep pressure to the tissue increased the amplitude and peak of the signal. It is expected that the simulation results combined with the previous experimental experience could provide a feasible scheme for improving the quality of finger volume pulse signal.
		                        		
		                        		
		                        		
		                        			Computer Simulation
		                        			;
		                        		
		                        			Fingers
		                        			;
		                        		
		                        			Finite Element Analysis
		                        			;
		                        		
		                        			Skin
		                        			;
		                        		
		                        			Software
		                        			
		                        		
		                        	
9.TEST YOUR KNOWLEDGE - An adult with a finger mass – is it benign or malignant?
Jazlan Jamaluddin ; Yeow Siong Siong
Malaysian Family Physician 2022;17(3):153-155
		                        		
		                        			
		                        			We described the case of a 42-year-old man who presented with left index finger mass persisting for 6 months. The mass was small and, painless and had gradually increased in size with limited finger flexion. Physical examination showed a firm mass over the volar surface of the left index finger. There was no tenderness, redness, warmth or punctum. The overlying skin was normal, and the mass did not transilluminate. Further examination of the head and neck, chest, upper limbs and neurovascular system revealed normal findings. No similar masses were found elsewhere in the body. Bedside ultrasound with further investigation and management confirmed the suspected diagnosis.
		                        		
		                        		
		                        		
		                        			Fingers
		                        			;
		                        		
		                        			 Soft Tissue Neoplasms
		                        			;
		                        		
		                        			 Neoplasms
		                        			
		                        		
		                        	
10.Clinical characteristics of 170 cases of macrodactyly.
Jing Heng WU ; Guang Lei TIAN ; Meng Meng TIAN ; Shan Lin CHEN
Journal of Peking University(Health Sciences) 2021;53(3):590-593
		                        		
		                        			OBJECTIVE:
		                        			To analyze the clinical characteristics of 170 cases of macrodactyly.
		                        		
		                        			METHODS:
		                        			Medical records of 170 macrodactyly patients at Beijing Jishuitan Hospital between March 2006 and October 2019, including demographic characteristics, clinical presentations, anatomical distributions, X-rays, pathological findings, and treatments, were reviewed. PIK3CA mutation analyses of 12 patients were also reviewed.
		                        		
		                        			RESULTS:
		                        			Disease incidence was similar across sex and geographical regions. Multiple-digit involvement was 3.9 times more frequent than single-digit involvement. In upper deformit: ies, the index finger, middle finger and thumb were mostly involved, and the second and third toes were the most affected on the foot. Two digits were affected more often than three digits, with the affected multiple digits were adjacent most time. The cases of progressive macrodactyly, in which the affected digits grew at a faster rate than the unaffected digits, were found more than static type. Most of progressive macrodactyly were noticed at birth. In terms of nerve involvement, affected fingers mostly occurred in the median nerve innervation area (79.4%) accompanied by median nerve and brunches enlargement and fat infiltration, i.e., nerve territory oriented; affected toes mostly occurred in the medial plantar nerve innervation area (89.1%), marked with overgrowth of adipose tissue with a lesser degree of neural overgrowth, i.e., lipomatous. Only 17 cases had comorbid of syndactyly. The metacarpal bones were involved only in progressive type of macrodactyly. Ten of the 12 cases subjected to PIK3CA mutation analysis were positive. Among all tested specimens, PIK3CA mutation levels ranged from 7% to 27%. In terms of tissue sources in which a mutation was found, adipose tissue had the highest mutation detection rate, followed by nerve and skin. All the DNA samples of blood from the 12 PIK3CA mutation-positive patients were negative.
		                        		
		                        			CONCLUSION
		                        			Macrodactyly fingers mostly occurred in the median nerve innervation area accompanied by median nerve and brunches enlargement and fat infiltration. The index and middle fingers were mostly involved. Macrodactyly toes mostly occurred in the medial plantar nerve innervation area, marked with overgrowth of adipose tissue with a lesser degree of neural overgrowth. The second and third toes were the most affected on the foot. A high proportion (83%) of isolated macrodactyly patients carry activating PIK3CA mutations. Adipose, nerve, and skin tissues provide the highest PIK3CA mutation detection yield among all types of tissue studied.
		                        		
		                        		
		                        		
		                        			DNA Mutational Analysis
		                        			;
		                        		
		                        			Fingers/abnormalities*
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Infant, Newborn
		                        			;
		                        		
		                        			Limb Deformities, Congenital
		                        			;
		                        		
		                        			Mutation
		                        			;
		                        		
		                        			Toes
		                        			
		                        		
		                        	
            

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