1."Step-up"surgical treatment strategy for patulous Eustachian tube.
Huiwen YANG ; Le XIE ; Yu SUN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2023;37(6):494-498
		                        		
		                        			
		                        			Patients with patulous Eustachian tubes(PET) usually suffer from annoying symptoms, such as tinnitus, autophony and aural fullness, due to the excessive opening of the Eustachian tube. There is no uniform standard of treatment, and conservative therapy combined with"Stepup"surgical intervention strategy is the main treatment. In this article, we reviewed various surgical treatments of patulous Eustachian tube in recent years, including key points of surgical operation, effectiveness, safety and complications. Full communication and evaluation are needed to establish appropriate patients' expectations preoperatively. A "Stepup" treatment strategy will be carried out, including conservative treatment, tympanic membrane surgery, Eustachian tube pharyngeal orifice constriction surgery, Eustachian tube tympanic orifice plug surgery and Eustachian tube muscle surgery, which aims to maintain normal Eustachian tube function and good middle ear ventilation.
		                        		
		                        		
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Eustachian Tube/surgery*
		                        			;
		                        		
		                        			Ear Diseases/diagnosis*
		                        			;
		                        		
		                        			Ear, Middle
		                        			;
		                        		
		                        			Tympanic Membrane/surgery*
		                        			;
		                        		
		                        			Tinnitus
		                        			;
		                        		
		                        			Otitis Media
		                        			
		                        		
		                        	
2.Endoscopic transoral resection of metastatic retropharyngeal lymph nodes in nasopharyngeal carcinoma via posteroinferior eustachian tube approach: a single center review study.
Zhen Lin WANG ; Jun Qi LIU ; Wei WEI ; Yan QI ; Ru Xiang ZHANG ; Qin Zhan REN ; Qiu Hang ZHANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2022;57(11):1328-1334
		                        		
		                        			
		                        			Objective: To summarize the clinical experience and treatment results of endoscopic transoral resection of metastatic retropharyngeal lymph nodes (MRPLN) in nasopharyngeal carcinoma (NPC) via posteroinferior eustachian tube approach. Methods: The clinical data of 37 patients with NPC who underwent endoscopic transoral surgery via posteroinferior eustachian tube approach for MRPLN in Xuanwu Hospital, Capital Medical University from 2010 to 2020 were analyzed retrospectively. There are 28 males and 9 females, aged from 31 to 72 years. The clinicopathological features such as gender, age, primary tumor stage, stage, side and size of MRPLN were recorded and analyzed. The surgical procedures of endoscopic transoral resection of MRPLN via posteroinferior eustachian tube approach were described. The MRPLN resection, perioperative complications and follow-up results were also summarized. Results: The primary tumors of 37 cases were determined as rT1 stage in 2 cases, rT2 stage in 30 cases and primary T2 stage in 5 cases in this study. There were 33 cases of unilateral MRPLN(89.2%), 4 cases of bilateral ones (10.8%), 36 cases in N1 stage, and 1 case in N3 stage. Single lymph node was detected in 23 cases(62.2%), and 2-5 lymph nodes in 14 cases(37.8%). Endoscopic transoral surgery via posteroinferior eustachian tube approach was completed in all cases. Total MRPLN resection was obtained in 35 cases (94.6%) with one-stage operation, and subtotal resection was achieved in 2 cases whose MRPLN involved the wall of internal carotid artery. No serious complications occurred in the perioperative period. During the follow-up period (median follow-up period 53.1 months), no recurrence of MRPLN was observed in patients who received total resection. And 8 patients (21.6%) died from different causes. Conclusion: Endoscopic transoral surgery via posteroinferior eustachian tube approach for MRPLN is a practicable and effective surgical option, but the long-term effect still needs longer follow-up and summary of bulk cases.
		                        		
		                        		
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Nasopharyngeal Carcinoma
		                        			;
		                        		
		                        			Eustachian Tube
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Lymph Nodes
		                        			;
		                        		
		                        			Nasopharyngeal Neoplasms
		                        			
		                        		
		                        	
3.Numerical simulation modeling of middle ear-eustachian tube ventilation based on Chinese digital visual human body.
Xiao Hui ZHU ; Qi TANG ; Meng Yao XIE ; Ruo Yan XUE ; Yong Li ZHANG ; Yi WU ; Xin HU ; Hua YANG ; Zhi Qiang GAO
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2022;57(4):452-457
		                        		
		                        			
		                        			Objective: To establish a three-dimensional model of middle ear-eustachian tube based on Chinese digital visual human dataset, and the deformation and pressure changes of the middle ear-eustachian tube system after eustachian tube opening are simulated by computer numerical simulation. Methods: The first female Chinese Digital Visual Human data was adopted. The images were imported by Amira image processing software, and the images were segmented by Geomagic software to form a three-dimensional model of middle ear-eustachian tube system, including eustachian tube, tympanum, tympanic membrane, auditory ossicles, and mastoid air cells system. The 3D model was imported into Hypermesh software for meshing and analysis. The structural mechanics calculation was carried out by Abaqus, and gas flow was simulated by Xflow. The tissue deformation and middle ear pressure changes during eustachian tube opening were numerically simulated by fluid-solid coupling algorithm. Several pressure monitoring points including tympanum, mastoid, tympanic isthmus, and external auditory canal were set up in the model, and the pressure changes of each monitoring point were recorded and compared. Results: In this study, a three-dimensional model of middle ear-eustachian tube and a numerical simulation model of middle ear ventilation were established, including eustachian tube, tympanum, mastoid air cells, tympanic membrane, and auditory ossicles. The dynamic changes of the model after ventilation could be divided into five stages according to the pressure. In addition, the pressure changes of tympanum and tympanic isthmus were basically synchronous, and the pressure changes of mastoid air cells system were later than that of tympanum and tympanic isthmus, which verified the pressure buffering effect of mastoid. The extracted pressure curve of the external auditory canal was basically consistent with that of tympanometry in terms of value and trend, which verified the effectiveness of the model. Conclusions: The numerical simulation model of middle ear-eustachian tube ventilation established in this paper can simulate the tissue deformation and middle ear pressure changes after eustachian tube opening, and its accuracy and effectiveness are also verified. This not only lays a foundation for further research, but also provides a new research method for the study of middle ear ventilation.
		                        		
		                        		
		                        		
		                        			China
		                        			;
		                        		
		                        			Ear, Middle
		                        			;
		                        		
		                        			Eustachian Tube
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Human Body
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Middle Ear Ventilation
		                        			
		                        		
		                        	
5.THE function and morphology study of eustachian tube based on sonotubometry and multi-slice spiral CT in normal subjects.
Liu Jun YOU ; Wei Gen CHEN ; Yi YUAN ; Dong Xiao NONG ; An Zhou TANG
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2021;56(5):431-435
		                        		
		                        			
		                        			Objective: In order to assess ET more comprehensively, sonotubometry (STM)combined with CT images were applied to investigate the opening features of eustachian tube (ET) in normal subjects. STM was also used as a monitor training ET opening maneuver and optimizing CT scan parameters. Methods: Following ET opening training monitored by STM, STM data of ET opening duration and maximum sound pressure from 13 healthy volunteers (10 males and 3 females, 22 to 26 years old) were acquired using maneuvers of swallowing and Valsalva in standing and supine positions. Two trials of CT scan, setting A (slice thickness 6.0 mm, manually simulated to 0.6 mm, reconstruction thickness 0.6 mm) for normal and Valsalva scans and setting B(slice thickness 0.4 mm,reconstruction thickness 0.4 mm)for Valsalva scan, were conducted in each subject. The bone area and cartilage area of ET were measured respectively in reconstructed CT images. Statistical software SPSS 19.0 was employed in data analysis. Results: The duration of ET opening and maximum sound pressure by Valsalva were longer and stronger than those by swallowing in both positions. For Valsalva maneuver, standing position resulted in longer ET opening duration compared to supine position (P<0.05). Under setting A, ET cartilage area was measured larger by Valsalva scan than by normal scan (P<0.05). By Valsalva scan, setting A captured larger ET cartilage area compared to setting B (P<0.05). CT setting B resulted in longer scan time in comparison to setting A (P<0.05). Conclusions: Techniques of STM in supine position plus CT scan under setting A can be combined by Valsalva passive ET opening. Not only the invisible ET lumen through routine CT scan can be illustrated, but also relevant ET open-close process is shown, therefore, this study provides the technique for ET research of function and structure.
		                        		
		                        		
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Deglutition
		                        			;
		                        		
		                        			Eustachian Tube/diagnostic imaging*
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Tomography, Spiral Computed
		                        			;
		                        		
		                        			Tomography, X-Ray Computed
		                        			;
		                        		
		                        			Valsalva Maneuver
		                        			;
		                        		
		                        			Young Adult
		                        			
		                        		
		                        	
6.Clinical and imaging features of middle ear hairy polyps.
Jun Hua LIU ; Chun Yan HU ; Rong Xian ZHOU ; Yan SHA
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2021;56(9):962-965
		                        		
		                        			
		                        			Objective: To collect the clinical cases of middle ear hairy polyp, and to summarize the imaging features. Methods: We retrospectively analyzed the clinical data of four cases middle ear hairy polyp confirmed by surgical and pathologic between January 2007 and January 2020 at the Affiliated Eye & ENT Hospital of Fudan University. There were three females, one male, with two left ears and two right ears, aged from 1 to 59 years. The CT and MRI imaging of the patients, and the corresponding clinical manifestations were analyzed. Results: Hairy polyps originated from tympanum in one case, originated from Eustachian tube in two cases, exhibiting recurrent otorrhea without evident inducement. The other case, hairy polyps originated from the Eustachian tube pharyngeal orifice and protruded into the nasopharyngeal cavity, with pharynx discomfort and aural fullness, endoscope showed offwhite polypoid mass with a little hair. All the four cases presented polypoid soft tissue masses on CT and MRI imaging, containing soft tissue wall and a large amount of adipose tissue, with soft tissue in the center of the mass which liked the core, and enhanced. MRI showed stratified arrangement of fat and soft tissue in the wall of the mass. Four cases all had surgical treatment, postoperative pathology examination presented that hair follicles, mature sebaceous glands and other skin appendages were found under squamous epithelium. A large amount of adipose tissue, part of muscle tissue, cartilage tissue, and some fibro-collagenous tissue were proliferated in the mass, accompanied by collagen degeneration. Conclusion: The middle ear hairy polyps has imaging characteristics, the polypoid soft tissue mass usually looks smooth and contains a large amount of adipose tissue, with a soft tissue in the center, and can be suggestively diagnosed by CT and MRI.
		                        		
		                        		
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Adult
		                        			;
		                        		
		                        			Child
		                        			;
		                        		
		                        			Child, Preschool
		                        			;
		                        		
		                        			Ear Diseases
		                        			;
		                        		
		                        			Eustachian Tube/pathology*
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Infant
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Middle Aged
		                        			;
		                        		
		                        			Nasopharynx/pathology*
		                        			;
		                        		
		                        			Polyps/pathology*
		                        			;
		                        		
		                        			Retrospective Studies
		                        			;
		                        		
		                        			Young Adult
		                        			
		                        		
		                        	
8.Change of Tympanogram after Chronic Otitis Media Surgery
Byung Gil CHOI ; Ji Soo LEE ; Sung Kwang HONG ; Hyo Jeong LEE ; Hyung Jong KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2019;62(10):554-561
		                        		
		                        			
		                        			BACKGROUND AND OBJECTIVES: Pre-operative eustachian tube function (ETF) is an important factor for the postoperative success after tympanoplasty, though much debates have been reported. In this study, we investigated the tympanogram changes after tympanoplasty, indirectly checking up ETF, to find out the relationship between tympanogram changes and associated factors of tympanoplasty. SUBJECTS AND METHOD: Included in this study were 238 cases of tympanoplasty (canal wall up mastoidectomy with tympanoplasty type I or tympanoplasty type I only) performed by one surgeon for chronic otitis media from January, 2012 to June, 2017. In all cases, tympanometric tests were undertaken at one month, three month, six month, and one year post-operatively, and pure tone audiometry tests were taken at 1 year, post operatively. RESULTS: The average hearing level and air-bone gap were 41.8±19.7 dB, and 17.1±9.3 dB, pre-operatively, and 29.9±21.1 dB, and 6.9±8.5 dB, 1 year post-operatively, respectively. Most of the cases showed improvement in hearing. The results of tympanometry showed that hearing improvement was greater for the A type than for the B or C type (p<0.001). The smaller the size of the tympanic membrane was, the higher, the type A tympanogram appeared to be (p=0.008). CONCLUSION: The estimation of pre-operative ETF using post-operative tympanogram changes can give insight to the degree and process of recovery of the normal middle ear after tympanoplasty.
		                        		
		                        		
		                        		
		                        			Acoustic Impedance Tests
		                        			;
		                        		
		                        			Audiometry
		                        			;
		                        		
		                        			Ear, Middle
		                        			;
		                        		
		                        			Eustachian Tube
		                        			;
		                        		
		                        			Hearing
		                        			;
		                        		
		                        			Methods
		                        			;
		                        		
		                        			Otitis Media
		                        			;
		                        		
		                        			Otitis
		                        			;
		                        		
		                        			Prognosis
		                        			;
		                        		
		                        			Tympanic Membrane
		                        			;
		                        		
		                        			Tympanoplasty
		                        			
		                        		
		                        	
9.Management of Acquired Cholesteatoma Associated With Patulous Eustachian Tube and Habitual Sniffing
Sung Won CHOI ; Dong Joo LEE ; Seok Hwan LEE ; Se Joon OH ; Soo Keun KONG
Clinical and Experimental Otorhinolaryngology 2019;12(4):385-391
		                        		
		                        			
		                        			OBJECTIVES: To investigate the effect of surgical treatment with eustachian tube (ET) catheter insertion in patients with acquired cholesteatoma associated with patulous eustachian tube (PET) and habitual sniffing. METHODS: Nine ears of nine patients (two men and seven women; age, 20 to 65 years; average, 37.9±12.0 years) of acquired cholesteatoma associated with PET and habitual sniffing who underwent cholesteatoma surgery with simultaneous additional ET catheter insertion were examined in this study. Successful treatment was defined as stoppage of sniffing, a relief of a PET handicap inventory-10 (PHI-10), an improvement of autophony grade and no cholesteatoma recurrence. RESULTS: ET catheter insertion was performed in all ears. Follow-up duration ranged from 16 to 37 months (average, 25.4 months). Cases consisted of nine pars flaccida type (100%). All patients obtained relief from aural symptoms and stopped sniffing. Postoperative PHI-10 scores were significantly lower than preoperative scores (P<0.001). During an average follow-up of 25.4 months, no cholesteatoma recurrence has occurred to date. One patient developed otitis media with effusion (OME) post-catheterization; OME resolved spontaneously without treatment. Four patients had a consecutive ET catheter insertion on the other side to resolve PET-related aural symptoms. CONCLUSION: In case of acquired cholesteatoma with PET and habitual sniffing, ET catheter insertion performed simultaneously with cholesteatoma surgery could help reduce aural symptoms and stop sniffing. Moreover, the procedure might help in preventing cholesteatoma recurrence.
		                        		
		                        		
		                        		
		                        			Catheters
		                        			;
		                        		
		                        			Cholesteatoma
		                        			;
		                        		
		                        			Ear
		                        			;
		                        		
		                        			Eustachian Tube
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Follow-Up Studies
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Otitis Media with Effusion
		                        			;
		                        		
		                        			Recurrence
		                        			
		                        		
		                        	
10.Comment on: Trans-Tympanic Cartilage Chip Insertion for Intractable Patulous Eustachian Tube
Journal of Audiology & Otology 2019;23(3):173-174
		                        		
		                        			
		                        			No abstract available.
		                        		
		                        		
		                        		
		                        			Cartilage
		                        			;
		                        		
		                        			Eustachian Tube
		                        			
		                        		
		                        	
            
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