NLRP3 Inflammasome as Therapeutic Targets in Inflammatory Diseases
10.4062/biomolther.2023.099
- Author:
Annamneedi Venkata PRAKASH
1
;
Il-Ho PARK
;
Jun Woo PARK
;
Jae Pil BAE
;
Geum Seon LEE
;
Tae Jin KANG
Author Information
1. Department of Pharmacy and Institute of Chronic Disease, Sahmyook University, Seoul 01795, Republic of Korea
- Publication Type:Review
- From:Biomolecules & Therapeutics
2023;31(4):395-401
- CountryRepublic of Korea
- Language:English
-
Abstract:
Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR’s), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.
