Effect and mechanism of serotonin-selective reuptake inhibitor on bone metabolism
- VernacularTitle:5-羟色胺选择性重摄取抑制剂对骨代谢的影响及机制
- Author:
Limin ZHOU
1
;
Yongxiang XU
1
Author Information
1. Dept. of Pharmacy，Dongguan People’s Hospital，Guangdong Dongguan 523059，China
- Publication Type:Journal Article
- Keywords:
serotonin-selective reuptake inhibitor;
bone metabolism;
mechanism;
signaling pathway;
bone formation;
bone
- From:
China Pharmacy
2023;34(23):2928-2933
- CountryChina
- Language:Chinese
-
Abstract:
Serotonin-selective reuptake inhibitor （SSRI） is the first-line drug for treating depression. SSRI mainly include fluoxetine， paroxetine， sertraline， fluvoxamine， citalopram and escitalopram， etc. SSRI has dual impact on bone metabolism. Short- term use of SSRI may have a positive impact on bone， but long-term use may lead to bone problems. This article summarizes the effects and mechanisms of SSRI on bone metabolism， indicating that SSRI can affect bone formation， bone resorption， mesenchymal stem cell differentiation， and regulate the expression of inflammatory cytokines. The impact of SSRI on bone metabolism can be achieved by affecting classical signaling pathways such as cAMP/PKA/CREB， Wnt/β-catenin， BMP/Smad， OPG/RANKL/RANK， and through centrally mediated effects.
