Design of small molecules targeting molecular chaperone system: review and perspective
10.16438/j.0513-4870.2023-0395
- VernacularTitle:靶向分子伴侣系统的小分子设计策略: 回顾与展望
- Author:
Huang-liang SHU
1
;
Qi-dong YOU
1
;
Lei WANG
1
Author Information
1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
- Publication Type:Research Article
- Keywords:
molecular chaperone system;
small molecule;
rug design
- From:
Acta Pharmaceutica Sinica
2023;58(8):2035-2046
- CountryChina
- Language:Chinese
-
Abstract:
Molecular chaperone system, which mainly consist of heat shock proteins family and their cochaperones, is crucial for maintaining proteostasis in life. It assists in folding, maturation and ubiquitin-proteasome-mediated degradation of proteins, thus to play a key role in cell proliferation and apoptosis. Functional disorder of molecular chaperone system is highly relevant to occurrence and development of multiple diseases including cancers, autoimmune disease/inflammatory, infective diseases, neurodegenerative disease, etc. Therefore, molecular chaperone system has long been regarded as potential drug targets. In this review, we outline the progress in the design of small molecules targeting molecular chaperone system and analyze the features of small molecules with different mechanisms. Finally, we put forward expects about potential development directions for future drug design in this field.
