Bioorthogonal click-to-release reaction for regulating iodo-BODIPY PDT probe
10.16438/j.0513-4870.2023-1071
- VernacularTitle:生物正交点击-释放反应对碘代氟硼荧光动力探针的调控研究
- Author:
Xin-yu YU
1
;
Jie LI
1
;
Yue LI
2
;
Ya-yue WANG
1
;
Wei SHI
3
;
Hao-xing WU
1
Author Information
1. Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu 610041, China
2. Research Core Facility of West China Hospital, Sichuan University, Chengdu 610041, China
3. Institute of Drug Clinical Trial·GCP, West China Second University Hospital, Sichuan University, Chengdu 610041, China
- Publication Type:Research Article
- Keywords:
photodynamic therapy probe;
bioorthogonal reaction;
ipyrromethene boron difluoride;
click-to-release reaction;
tetrazine
- From:
Acta Pharmaceutica Sinica
2023;58(11):3400-3407
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we synthesized six tetrazine-dipyrromethene boron difluoride (BODIPY) probes and achieved a remarkable up to 14-fold increase in singlet oxygen yield via tetrazine bioorthogonal click-to-release reactions. We systematically investigated the photodynamic activity of these probes, revealing crucial structure-activity relationships. Additionally, we evaluated the stability and release kinetics of these probes and identified P5 and P6 as ideal candidates for photodynamic therapy in live cells. This innovative strategy opens new avenues for fine-tuning the photodynamic properties of BODIPY dyes, thereby expanding their utility in cancer therapy.
