Preparation of 3D printed metoprolol tartrate chewable tablets and optimization of printing process
10.16438/j.0513-4870.2023-0143
- VernacularTitle:3D打印酒石酸美托洛尔咀嚼片的制备及打印工艺优化
- Author:
Shan-shan WANG
1
;
Xiao-lu HAN
2
;
En LIANG
2
;
Cong-hui LI
2
;
Chun-yan LIU
3
;
Ming-yuan LI
4
;
Zeng-ming WANG
2
;
Peng YU
4
;
Ai-ping ZHENG
2
Author Information
1. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
3. College of Pharmacy, North China University of Science and Technology, Tangshan 063210
4. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
- Publication Type:Research Article
- Keywords:
3D printing;
semi-solid extrusion;
metoprolol tartrate;
quality by design;
personalized dose
- From:
Acta Pharmaceutica Sinica
2023;58(9):2811-2817
- CountryChina
- Language:Chinese
-
Abstract:
With the growing demand of personalized medicine for children, it is especially important to develop medicines for children. In this study, using metoprolol tartrate as model drug, we developed 3D printed chewable tablets suitable for children with automated dosage distribution using semi-solid extruded (SSE) 3D printing technology. Based on the quality by design concept, this study prepared a semi-solid material with good printability using gelatin as the substrate, constructed 3D models and printed tablets with the aid of computer-aided design. The printing parameters were optimized and determined as follows: print temperature of 35-37 ℃, print speed of 25 mm·s-1, fill rate of 15%, and number of outer profile layers of 2. Subsequently, the printing process and the quality uniformity of the tablets were verified, and a linear relationship between the dose and the number of model layers was obtained. Finally, 3D printed chewable tablets were superior in terms of appearance, dose accuracy and compliance compared with traditional split-dose commercially available tablets. In this study, 3D printed metoprolol tartrate chewable tablets with good performance were successfully prepared to address the personalized medication needs of pediatric patients.
