Prevalence of chronic hepatitis C and liver function impairment in Taixi Region in 2018 - 2021
10.3969/j.issn.1006-2483.2023.06.027
- VernacularTitle:2018—2021年泰西地区慢性丙型肝炎流行特征及肝脏功能损害影响因素分析
- Author:
Zhenzhen LUO
1
;
Yuan JI
2
;
Haiying TIAN
1
Author Information
1. Department of Laboratory , The Second Affiliated Hospital of Shandong First Medical University，Taian , Shandong 271000 , China
2. School of Public Health and Health Management , Shandong First Medical University，Taian , Shandong 271000 , China
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis C;
Liver function impairment;
Epidemic Trends
- From:
Journal of Public Health and Preventive Medicine
2023;34(6):112-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prevalence trend of chronic hepatitis C and liver function impairment in Taixi area from 2018 to 2021, and to provide theoretical basis for preventing liver function impairment in hepatitis C patients in Taixi area. Methods The data of hepatitis C cases reported in Taixi were downloaded from the infectious disease reporting Information management system of Chinese Center for Disease Control and Prevention, and the epidemiological characteristics of hepatitis C were analyzed by descriptive epidemiological methods. The clinical data including gender, age, place of residence, smoking history, drinking history, therapeutic drugs, genotyping and other clinical data were collected from HIS system of the hospital. Patients were divided into liver function injury group and control group according to whether they had liver function injury. Univariate analysis and logistic regression were used to analyze the factors of liver function injury in hepatitis C patients in Taixi area. Results Among the 550 cases reported from 2018 to 2021, there were no deaths, including 292 males and 258 females. The male cases were more than the female cases, and the average age was (53.47±5.74) years old. There was no significant difference in the composition of male and female cases among different age groups (χ2=1.472,P>0.05). From 2018 to 2021, the proportion of patients aged 40 to 59 was significantly higher than that of patients aged 20 to 39 and ≥60. The occupation composition was mainly farmers, accounting for 44.36% (244/550), and 287 cases (52.18%) lived mainly in rural areas. From 2018 to 2021, 129 (23.45%) of 550 patients with hepatitis C had liver function injury. ALT, AST and GGT values in the liver function injury group were significantly higher than those in the control group (P<0.05). The ALB value of liver function injury group was significantly lower than that of control group (P<0.05). There were statistically significant differences between the two groups in mean age, drinking history, diabetes mellitus, genotyping, HCV-RNA viral load, CD4+CD25+Treg (P<0.05). CD4+CD25+Treg>5%, genotype 1b and high load of HCV-RNA were independent risk factors for liver function impairment in hepatitis C patients in Taixi area (P<0.05). Conclusion The incidence of hepatitis C was high in Taixi area from 2018 to 2021, and patients with CD4+CD25+Treg<5%, genotype 1b and high load of HCV-RNA had a high risk of liver function impairment. Therefore, active treatment should be carried out to reduce the occurrence of liver function injury.
