Adverse reactions and precautions of teprotumumab in the treatment of thyroid-associated ophthalmopathy
10.3980/j.issn.1672-5123.2023.12.09
- VernacularTitle:替妥木单抗在甲状腺相关眼病治疗中的不良反应及预防策略
- Author:
Yan-Fei ZHU
1
;
Cheng-Cheng ZENG
1
;
Rui-Li WEI
1
Author Information
1. The Second Affiliated Hospital of Naval Medical University;Shanghai Changzheng Hospital, Shanghai 200003, China
- Publication Type:Journal Article
- Keywords:
thyroid-associated ophthalmopathy;
teprotumumab;
adverse reaction;
insulin-like growth factor 1 receptor
- From:
International Eye Science
2023;23(12):1983-1987
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid-associated ophthalmopathy(TAO)is an autoimmune disease associated with thyroid dysfunction that can significantly impact quality of life, result in visual impairment and facial disfigurement. Traditional treatments are often unsatisfactory. Studies have shown that teprotumumab, a human monoclonal antibody that can inhibit insulin-like growth factor 1 receptor(IGF-1R), has become an emerging targeted drug for TAO. Although the drug has proven to be effective and relatively safe in the treatment of TAO, adverse reactions are worthy of attention of ophthalmologists with the continuous promotion of clinical application, including hearing impairment, hyperglycemia, diarrhea, muscle spasms, infusion reactions, cognitive decline, thyroid suppression, alopecia, nausea and fatigue. Teprotumumab was generally well tolerated, with most adverse events being mild or moderate in severity. This paper aims to review the adverse reactions and precautions of teprotumumab in the treatment of TAO.
