Research progress of TRPV4 in glaucoma optic neuropathy
10.3980/j.issn.1672-5123.2023.12.07
- VernacularTitle:TRPV4在青光眼性视神经病变中的研究进展
- Author:
Yu HUANG
1
;
Xin XIA
1
;
Ya-Sha ZHOU
1
;
Qing-Hua PENG
1
Author Information
1. Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
- Publication Type:Journal Article
- Keywords:
transient receptor potential channel vanillic acid subfamily 4(TRPV4);
glaucomatous optic neuropathy;
glaucoma;
optic nerve injury;
optic neuropathy
- From:
International Eye Science
2023;23(12):1973-1977
- CountryChina
- Language:Chinese
-
Abstract:
Glaucomatous optic neuropathy(GON)is the difficulty of glaucoma treatment. In recent years, a variety of theories have been put forward about the pathogenesis of GON, but none of them can explain the principle of optic neuropathy caused by all types of glaucoma, which makes the disease difficult to treat in clinical treatment and is not conducive to early intervention. The latest research found that the transient receptor potential channel vanillic acid subfamily 4(TRPV4)in the retina plays an important role in various pathogenesis of GON. This article will review TRPV4 and its role in the occurrence and development of GON in order to find a common “connection point” for the multiple mechanism theories of GON, which will contribute to further understanding and clinical treatment of the disease.
