Traditional Chinese Medicine Treats Ulcerative Colitis by Intervening in Mitochondrial Quality Control： A Review
10.13422/j.cnki.syfjx.20230901
- VernacularTitle:中医药干预线粒体质量控制治疗溃疡性结肠炎研究进展
- Author:
Lingfeng YANG
1
;
Ying ZHU
2
;
Bin YU
2
;
Ruifang LIN
1
;
Yin XU
2
Author Information
1. Hunan University of Chinese Medicine，Changsha 410208，China
2. The First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410007，China
- Publication Type:Journal Article
- Keywords:
mitochondrion;
mitochondrial quality control;
traditional Chinese medicine;
ulcerative colitis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(23):245-252
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC）， a chronic inflammatory bowel disease with the accumulation of colorectal mucosa and submucosa， has a risk of developing into cancer. In recent years， the incidence of UC has been on the rise worldwide. However， its pathogenesis has not been fully elucidated by modern medicine， and even the remission rate of the latest drugs is lower than 50%， which seriously affects the patients' work and quality of life. Mitochondria， as the "power station" of eukaryotic cells， are involved in a variety of physiological processes such as the production of reactive oxygen species and the production of adenosine triphosphate by oxidative phosphorylation， and their dysfunction can lead to a series of diseases. Mitochondrial quality control （MQC） is an important way to maintain the stability of mitochondrial form， quantity， and quality. Studies have shown that MQC disorders characterized by low mitochondrial biogenesis， excessive mitochondrial oxidative stress， mitochondrial autophagy defects， mitochondrial dynamics disorders， and calcium regulation abnormalities are closely related to the occurrence and development of UC. Although progress has been achieved in the treatment of UC by traditional Chinese medicine （TCM） which can regulated MQC in a multi-pathway and multi-target manner in recent years， a review on the treatment of UC by TCM via the intervention in MQC remains to be carried out. Therefore， this paper summarized the TCM treatment of UC by regulating MQC， aiming to provide new ideas for the clinical treatment of UC by TCM.
