High-Efficiency Cationic Labeling Algorithm of Macroaggregated Albumin with 68 Gallium
10.1007/s13139-021-00687-6
- Author:
Uğur AYŞE
1
;
Gültekin AZIZ
;
Yüksel DOĞANGÜN
Author Information
1. Education and Research Hospital, Department of Nuclear Medicine, Pamukkale University, Denizli, Turkey
- Publication Type:ORIGINAL ARTICLE
- From:Nuclear Medicine and Molecular Imaging
2021;55(2):79-85
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:The generator product radionuclide gallium-68( 68 Ga) is widely used for PET/CT imaging agents and the 68 Ga-labeled MAA is an attractive alternative to 99m Tc-labeled MAA. Using a commercially available MAA labeling kit for 99m Tc, we presented a reliable synthesis protocol with a highly efficient, organic solvent-free cationic method in GMP conditions in the Scintomics automated synthesis unit.
Methods:The labeling process was performed by incubating for 7 min at 90 ° C in the borax vial containing the generator product68 GaCl 3 MAA-HEPES eluted from the PSH + cartridge with 1.5 mL 5 molar NaCl. Quality control of the final product content was examined, and radiopharmaceutical production was carried out in accordance with GMP guidelines.
Results:68 Ga eluted from the generator was obtained in more than 99% radiochemical purity and efficiency. In this case, the labeling efficiency was found to be >99%. When the results of SEM-EDX analysis in the final product were examined, it was determined that most of toxic metals were no appreciable in the product content.
Conclusions:The radiochemical and chemical purity of the final product allows direct use without purification steps to remove “free 68 Ga” or other toxic compounds.
