Efficacy comparison of intravitreal injection of Conbercept versus Aflibercept in the treatment of pachychoroid neovasculopathy
10.3980/j.issn.1672-5123.2023.11.26
- VernacularTitle:玻璃体腔注射康柏西普与阿柏西普治疗厚脉络膜新生血管病变的疗效比较
- Author:
Xiao-Yu WANG
1
;
Yuan LIU
1
;
Jing-Wen HOU
1
;
Tian ZHAN
1
;
Ai-Yuan WANG
1
Author Information
1. Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning Province, China
- Publication Type:Journal Article
- Keywords:
Conbercept;
Aflibercept;
pachychoroid neovasculopathy;
clinical efficacy
- From:
International Eye Science
2023;23(11):1902-1906
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To observe and compare the clinical efficacy and safety of intravitreal injection of conbercept or aflibercept in the treatment of pachychoroid neovasculopathy(PNV).METHODS:Retrospective case-control study. A total of 33 patients(35 eyes)diagnosed as PNV in our hospital from February 2018 to October 2022 were divided into 14 cases(14 eyes)in conbercept group and 19 cases(21 eyes)in aflibercept group according to the treatment methods. The best corrected visual acuity(BCVA), subfoveal choroidal thickness(SFCT)and central macular thickness(CMT), injection times and clinical complications of the two groups were compared before and 1, 3 and 6mo after treatment.RESULTS:BCVA, CMT and SFCT in both groups were significantly improved after 1, 3 and 6mo of treatment(all P<0.05). During the whole follow-up period, the number of intravitreal injections in the two groups were 2(2, 3)and 2(1.5, 2)respectively, and there was no significant difference(P=0.423). No serious complications occurred during the treatment of the two groups.CONCLUSION:Both intravitreal injections of conbercept and aflibercept can treat PNV with similar therapeutic effects. The desired clinical outcome is achieved by improving the anatomy while improving visual acuity.
