Progress of mechanism of metformin against colorectal cancer
10.3760/cma.j.cn115355-20220407-00210
- VernacularTitle:二甲双胍抗结直肠癌机制的研究进展
- Author:
Hongzhen WANG
1
;
Yaoping LI
Author Information
1. 山西医科大学第五临床医学院，太原 030000
- Keywords:
Colorectal neoplasms;
Metformin;
Diabetes mellitus
- From:
Cancer Research and Clinic
2023;35(6):466-469
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a common gastrointestinal malignant tumor with morbidity and mortality rising year by year. In recent years, the studies in and out of China have reported that metformin could inhibit the growth of colorectal cancer cells and improve the prognosis of patients by indirectly reducing the levels of insulin and glucose in the blood, or directly activating the AMP-activated protein kinase signaling pathways, promoting apoptosis of tumor cells, enhancing sensitivity to chemotherapy, inhibiting inflammatory responses, affecting the intestinal flora, and regulating the immune function, etc. This article reviews the current research status and controversies related to metformin against colorectal cancer, in an effort to provide new evidences for the treatment of colorectal cancer.
