Roles of P2X7 receptor and NLRP3 inflammasome in inflammatory diseases
10.3760/cma.j.cn112309-20221017-00340
- VernacularTitle:P2X7受体及NLRP3炎性小体在炎症性疾病中的研究进展
- Author:
Yuanyuan TANG
1
;
Zhangping HE
;
Yimou WU
Author Information
1. 南华大学衡阳医学院病原生物学研究所，衡阳 421001
- Keywords:
P2X7 receptor;
NLRP3;
Inflammatory diseases;
Tumor;
Inhibitor
- From:
Chinese Journal of Microbiology and Immunology
2023;43(4):316-321
- CountryChina
- Language:Chinese
-
Abstract:
Purinergic 2X7 receptor (P2X7R) is an ionotropic receptor that is involved in various inflammatory diseases through affecting the release of inflammatory cytokines such as IL-1β and IL-18 after inducing the activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3). In recent years, the P2X7R/NLRP3 signaling pathway has become one of the more studied pathways in inflammatory diseases, and some inhibitors of P2X7R and NLRP3 have already been used in early clinical treatment. In this paper, the progress in P2X7R and NLRP3 was summarized, aiming to provide reference for further investigation on the roles of P2X7R/NLRP3 in the pathogenesis of tumors and inflammatory diseases and the potential of P2X7R/NLRP3 as therapeutic targets.
