Research progress in the relationship between loss of heterozygosity events and antifungal drug resistance in Candida albicans
10.3760/cma.j.cn112309-20220704-00224
- VernacularTitle:白念珠菌的杂合性丢失事件与抗真菌药物耐药表型相关性研究进展
- Author:
Rongchen DAI
1
;
Xin FAN
;
Canran JIANG
;
Jie GONG
;
Meng XIAO
;
Conghua JI
Author Information
1. 浙江中医药大学公共卫生学院，杭州 310053
- Keywords:
Fungi;
Drug resistance;
Loss of heterozygosity;
Parasexuality
- From:
Chinese Journal of Microbiology and Immunology
2023;43(4):309-315
- CountryChina
- Language:Chinese
-
Abstract:
Candida albicans as a pathogen of great clinical significance can widely colonize in many ecological niches of human body, especially in the immunocompromised population. Currently, antifungal drugs that can be used in clinical treatment are very limited. However, the genome of Candida albicans has a high rate of mutation, which can help it quickly develop resistance to antifungal drugs. Therefore, drug resistance in Candida albicans remains a great threat to clinical practice. This article focused on the frequent loss of heterozygosity (LOH) events in Candida albicans, summarized the association between LOH and other genomic variants and discussed the relationship of the frequency of de novo mutations, heterozygous status of key drug resistance genes and reproductive pattern with antifungal drug resistance.
