Progress in pathogenesis of perinatal group B streptococcal infection
10.3760/cma.j.cn113903-20220526-00553
- VernacularTitle:围产期B族链球菌感染致病机制的研究进展
- Author:
Yao ZHU
1
;
Chao CHEN
;
Xinzhu LIN
Author Information
1. 厦门大学附属妇女儿童医院（厦门市妇幼保健院）新生儿科（厦门市围产-新生儿感染重点实验室），厦门 361003
- Keywords:
Streptococcus agalactiae;
Streptococcal infections;
Infectious disease transmission, vertical;
Pregnancy complications, infectious;
Virulence factors;
Immu
- From:
Chinese Journal of Perinatal Medicine
2022;25(12):919-924
- CountryChina
- Language:Chinese
-
Abstract:
Group B Streptococcus (GBS) is a major cause of severe perinatal infection, stillbirth, premature delivery, and neonatal infectious diseases. Ascending infection after vaginal colonization is the main route of prenatal GBS transmission. The pathogenic mechanism of GBS from asymptomatic colonization to invasive infection mainly relates to virulence factors, the regulation of two-component systems and immune escape. This paper reviews progress in pathogenic mechanism of perinatal GBS infection in recent years, aiming to provide a theoretical basis for the development of vaccines and new treatment approaches against GBS.
