Renal thrombotic microangiopathy induced by targeted therapy combined with immunotherapy: a case report
10.3760/cma.j.cn441217-20221028-01040
- VernacularTitle:靶向联合免疫治疗引发肾脏血栓性微血管病1例
- Author:
Shizhu ZHAO
1
;
Li XIANG
;
Yun ZOU
;
Hua ZHOU
;
Min YANG
Author Information
1. 常州市第一人民医院肾内科，常州 213003
- Keywords:
Thrombotic microangiopathies;
Molecular targeted therapy;
Immunotherapy;
Antiphospholipid antibody
- From:
Chinese Journal of Nephrology
2023;39(7):542-545
- CountryChina
- Language:Chinese
-
Abstract:
Targeted therapy and immunotherapy have achieved great success in treating various solid and non-solid tumors, but the incidence of drugs-related adverse events is relatively high. The paper reports a case of renal thrombotic microangiopathy in an intrahepatic cholangiocarcinoma patient who underwent targeted therapy combined with immunotherapy. During the treatment, the tumor burden relieved continuously, but the patient developed proteinuria, edema and hypertension. The ADAMTS13 activity and inhibitors were normal, while the antiphospholipid antibody was positive. The patient was finally diagnosed as glomerular thrombotic microangiopathy with immune complex deposition by renal biopsy. After the cease of the antineoplastic agents and treatment with "cordyceps preparations" and "α-keto acids", the patient's blood pressure dropped to normal, her urine protein turnned to weakly positive, and her renal function remained stable.
