Pathogenesis of depression: focusing on protein levels and genetic abnormalities
10.3760/cma.j.cn113694-20230309-00170
- VernacularTitle:抑郁症发病机制：聚焦蛋白水平与基因异常
- Author:
Huiqin WANG
1
;
Naihong CHEN
Author Information
1. 湖南中医药大学药学院 湖南省中药饮片标准化及功能工程技术研究中心，长沙 410208
- Keywords:
Depressive disorder;
Protein;
Gene;
Pathogenesis
- From:
Chinese Journal of Neurology
2023;56(9):1078-1083
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common psychiatric disorder characterized by a wide range of clinical manifestations, including depressed mood, psychomotor retardation, diminished motivation, anhedonia, despair, and even suicidality. The heterogeneity of the features of depression indicates the diversity of its pathogenesis. Protein levels and their genetic abnormalities are essential factors in the pathogenesis of depression. This review focuses on the levels and genetic abnormalities of depression-related proteins to further elaborate the pathogenesis of depression and presents current problems and challenges to provide a theoretical foundation for the development of novel antidepressant medications.
