Research progress on the common pathogenesis of Parkinson′s disease and rapid eye movement sleep behavior disorder

VernacularTitle:帕金森病和快速眼球运动睡眠期行为障碍的共同发病机制研究进展
Author: Xin QIN ¹ ; Lin CHEN ; Zhiyong SHENG ; Wei HUANG
Author Information

1. 南昌大学第二附属医院神经内科，南昌　330006
Keywords: Parkinson disease; REM sleep behavior disorder; Pathogenesis; Biomarkers; Early diagnosis; Treatment
From: Chinese Journal of Neurology 2023;56(4):458-463
CountryChina
Language:Chinese
Abstract: Parkinson′s disease (PD) is one of the neurodegenerative diseases with high incidence in middle-aged and elderly people, and its prodromal stage lasts for several years to decades, markers of disease progression in prodromal stage are important basis for early recognition and diagnosis of PD. Current studies have shown that rapid eye movement sleep behavior disorder (RBD) is the specific clinical prodromal symptoms of PD, and has some of the same mechanisms as PD. Part of the same mechanisms develop regularly in the process of RBD converting to PD, which may produce valuable prodromal markers of PD. This paper reviews the common mechanisms of PD and RBD, in order to provide some ideas for the early clinical diagnosis and treatment of PD.