Advances in conditioning regimens for allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia
10.3760/cma.j.cn421203-20221213-00332
- VernacularTitle:老龄急性髓系白血病异基因造血干细胞移植的预处理进展
- Author:
Shan JIANG
1
;
Wei SHI
;
Linghui XIA
Author Information
1. 华中科技大学同济医学院附属协和医院血液科，武汉 430022
- Keywords:
Acute myeloid leukemia;
Allogeneic hematopoietic stem cell transplantation;
transplantation conditioning;
Elderly patient
- From:
Chinese Journal of Organ Transplantation
2023;44(7):440-445
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a sole viable treatment for acute myeloid leukemia (AML). As the median age of AML is approaching 68 years and the global population is aging, allo-HSCT for is becoming more vital for elderly AML patients (60 years and over). Conditioning regimen is important in determining the clinical outcomes of post-allo-HSCT patients.This review summarized the classic and latest conditioning regimens and evaluated their respective clinical outcomes.Clinicians may appreciate the advantages of each conditioning regimen and formulate optimal options for elderly AML patients.
