Analysis of clinical features of seven patients with granular parakeratosis after benzalkonium chloride exposure
10.35541/cjd.20220769
- VernacularTitle:接触苯扎氯铵后发生颗粒状角化不全7例临床特征分析
- Author:
Bin HU
1
;
Qiang CHEN
;
Meizhen FANG
;
Bin LAI
;
Yun XIA
;
Meng HUANG
;
Xiaoyong ZHOU
;
Fei SU
;
Liuqing CHEN
Author Information
1. 武汉市第一医院皮肤科，武汉 430022
- Keywords:
Granular parakeratosis;
Benzalkonium chloride;
Clinical manifestation;
Histopathological manifestations
- From:
Chinese Journal of Dermatology
2023;56(4):316-319
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize clinical manifestations and histopathological features of granular parakeratosis (GP) after exposure to benzalkonium chloride.Methods:A retrospective analysis was performed on 7 GP cases with a history of benzalkonium chloride exposure in the Department of Dermatology at Wuhan No.1 Hospital from April to August 2022. Data were collected on the general condition, skin lesion manifestations, pathological examination, treatment, and follow-up of the patients, and retrospectively analyzed.Results:The 7 adult patients with GP typically presented with erythema and brown scales in the intertriginous area, exhibiting an annular distribution pattern. All the 7 patients reported recent exposure to disinfectants containing benzalkonium chloride. A total of 10 skin biopsies were taken from the 7 patients. Histopathological examination showed characteristic hyperkeratosis and fine blue-gray parakeratotic granules in the stratum corneum. All skin lesions improved 1 month after cessation of exposure to benzalkonium chloride.Conclusion:GP has a distinct clinical pattern and histopathological manifestations, and a history of exposure to benzalkonium chloride can be helpful for the diagnosis of GP.
