Effects of glucagon-like peptide-1 on male reproductive function
10.3760/cma.j.cn311282-20230329-00139
- VernacularTitle:胰升糖素样肽-1对男性生殖功能的影响
- Author:
Deshan YIN
1
;
Li XIA
;
Rui WEI
Author Information
1. 北京大学第三医院内分泌科，北京 100191
- Keywords:
Glucagon-like peptide-1;
Diabetes;
Male reproductive function
- From:
Chinese Journal of Endocrinology and Metabolism
2023;39(8):719-721
- CountryChina
- Language:Chinese
-
Abstract:
With the younger onset of diabetes, the reproductive dysfunction caused by diabetes has received widespread attention. Hyperglycemia and insulin resistance, the main features of diabetes, are high-risk factors for male reproductive dysfunction. Obesity, the common co-morbidity of diabetes, may aggravate the progression of reproductive dysfunction. Glucagon-like peptide-1(GLP-1) and its receptor agonists improve the overall health status by lowering blood glucose, reducing body weight, and inhibiting inflammatory response, which indirectly exerts protective effects on the reproductive system. GLP-1 also protects reproductive function by regulating the neuroendocrine function, and directly acting on the supporting cells and interstitial cells of the testis. However, some studies did not find the protective effects. High-quality clinical studies are needed. GLP-1 receptor agonists may be a therapeutic option to improve reproductive dysfunction in diabetic men.
