Research progress on the use of Rhizoma coptidis extract against Alzheimer's disease
10.3760/cma.j.issn.0254-9026.2023.04.018
- VernacularTitle:黄连提取物抗阿尔茨海默病的研究进展
- Author:
Lijie YANG
1
;
Zhaohui YAO
Author Information
1. 武汉大学人民医院老年病科，武汉 430060
- Keywords:
Alzheimer's disease;
Rhizoma coptidis extract;
Berberine;
Amyloid β protein;
Tau protein
- From:
Chinese Journal of Geriatrics
2023;42(4):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Rhizoma coptidis extract has a variety of pharmacological activities, including alleviating cognitive impairment in Alzheimer's disease(AD). The main mechanisms of its anti-AD activity include reducing the production of amyloid β(Aβ), inhibiting the phosphorylation of Tau protein, inhibiting cholinesterase, anti-inflammation, anti-oxidation, improving apoptosis, etc.This paper reviewed the anti-AD effect of Rhizoma coptidis extract and the specific mechanisms, aiming to provide a theoretical basis for relevant research and clinical practice.
