Research and application of Raman spectroscopy in the diagnosis and therapy of brain glioma
	    		
		   		
		   			
		   		
	    	
    	 
    	10.3760/cma.j.cn321828-20220507-00144
   		
        
        	
        		- VernacularTitle:拉曼光谱在脑胶质瘤诊疗中的研究与应用
 
        	
        	
        	
        		- Author:
	        		
		        		
		        		
			        		Qingqing ZHOU
			        		
			        		
			        		
			        			1
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Jingxing GUO
			        		
			        		;
		        		
		        		
		        		
			        		Qing XU
			        		
			        		;
		        		
		        		
		        		
			        		Lijun ZHU
			        		
			        		;
		        		
		        		
		        		
			        		Guangming LU
			        		
			        		
		        		
		        		
		        		
		        		
		        			
			        		
			        		Author Information
			        		
		        		
		        		
			        		
			        		
			        			1. 解放军东部战区总医院放射诊断科、南京医科大学附属金陵临床医学院,南京 210002
			        		
		        		
	        		
        		 
        	
        	
        	
        	
        		- Keywords:
        			
	        			
	        				
	        				
			        		
				        		Glioma;
			        		
			        		
			        		
				        		Spectrum analysis, Raman;
			        		
			        		
			        		
				        		Trends
			        		
			        		
	        			
        			
        		
 
        	
            
            
            	- From:
	            		
	            			Chinese Journal of Nuclear Medicine and Molecular Imaging
	            		
	            		 2023;43(9):566-570
	            	
            	
 
            
            
            	- CountryChina
 
            
            
            	- Language:Chinese
 
            
            
            	- 
		        	Abstract:
			       	
			       		
				        
				        	Brain glioma invariably relapses since the tumor is difficult to remove completely. Accurate identification of tumor subtypes and tracing of tumor boundaries intraoperatively are the key clinical issues. Raman spectroscopy has a good application prospect in the intraoperative diagnosis of brain glioma due to its advantages of nondestructive, label-free, histology imaging and high specificity. In this article, the research and application of Raman spectroscopy in the in vitro diagnosis and intraoperative navigation-related diagnosis and treatment of brain glioma are reviewed.