Advances in the study of gene body methylation and tumors
10.3760/cma.j.cn113884-20220625-00257
- VernacularTitle:基因体甲基化与肿瘤的研究进展
- Author:
Qi WANG
1
;
Yongjun CHEN
Author Information
1. 华中科技大学同济医学院附属同济医院胆胰外科，武汉 430030
- Keywords:
DNA methylation;
Neoplasms;
Gene body methylation
- From:
Chinese Journal of Hepatobiliary Surgery
2023;29(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is an important epigenetic regulatory mechanism, including gene promoter methylation and gene body methylation. Abnormal DNA methylation is closely related to the development and progression of malignant tumors, and the correlation between promoter methylation and tumors has been more clearly described previously. However, with the in-depth study of genome-wide DNA methylation, it has been found that there are more extensive methylation levels in gene body regions, which also play an important role in tumor-related gene expression, cell differentiation and tumor development. In this paper, we review the effects of gene bodymethylation on tumors in recent years and provide clues for the research and application of gene body methylation in the field of tumors by elaborating the role and regulatory mechanism of gene body methylation on tumors.
