Research progress on ferroptosis in radiosensitivity of malignant tumors
10.3760/cma.j.cn113030-20220616-00212
- VernacularTitle:铁死亡在恶性肿瘤放疗敏感性中的研究进展
- Author:
Wei LIN
1
;
Yadong WU
Author Information
1. 贵州医科大学口腔医学院，贵州医科大学附属口腔医院口腔颌面外科教研室，贵阳 550000
- Keywords:
Ferroptosis;
Neoplasms, malignant;
Radiotherapy;
Radiosensitivity;
Synergistic therapy
- From:
Chinese Journal of Radiation Oncology
2023;32(6):572-576
- CountryChina
- Language:Chinese
-
Abstract:
As one of the most effective treatments for cancer, radiotherapy(RT)can eliminate the tumor cells and improve the survival rate of cancer patients. However, radiation resistance of tumor cells remarkably reduces the efficacy of RT. Therefore, it is significant to investigate the resistance mechanism and explore corresponding therapy for cancer. Ferroptosis is a novel mode of programmed cell death. Numerous studies have indicated an intimate connection between ferroptosis and tumor radiosensitivity. The mechanism involves lipid reactive oxygen species accumulation, glutathione metabolism and iron metabolism. It has been reported that ferroptosis inducers can act effectively and synergistically with RT, promote radiosensitivity and further improve tumor prognosis. In this article, relevant mechanisms and research progress were reviewed, and the future development direction of this field was discussed, aiming to provide reference for clinical trials and mechanism research of RT for malignant tumors.
