Research advances in immune response of stereotactic body radiotherapy
10.3760/cma.j.cn113030-20211117-00473
- VernacularTitle:立体定向放射治疗的免疫效应研究进展
- Author:
Xiaojun LIU
1
;
Wen MA
;
Chenru MA
;
Wanjia QIAO
;
Shuping LI
Author Information
1. 甘肃省人民医院放疗二科，兰州 730000
- Keywords:
Radiotherapy;
Stereotactic body radiotherapy;
Immunotherapy;
Abscopal effect;
Tumor microenvironment
- From:
Chinese Journal of Radiation Oncology
2023;32(2):159-163
- CountryChina
- Language:Chinese
-
Abstract:
The mechanisms of radiotherapy (RT) in cancer treatment are both by immunity and non-immunity pathways. According to different absorbed doses, the immune modulating effect of RT comprises of tumor microenvironment modulating effect, immune-modulatory effect as well as immune-ablative effect. RT could improve the therapeutic efficacy of immunotherapy, while immunotherapy could enlarge the immunity activating effect induced by RT in turn. Therefore, RT is emerging as a valuable partner of cancer immunotherapy. RT regimens have a vital impact on immunity within tumor microenvironment. Stereotactic body RT (SBRT) has obvious advantages regarding interferon production and abscopal effect. At present, potentially sub-ablative RT regimen of 8 Gy plus 3 fractionations is the most widely used SBRT. Several novel RT regimens, such as hybrid fractionation, singular site irradiation and multisite irradiation, have been designed to maximize the immune induction effect and improve the combination efficacy with immunotherapy in metastatic malignancies. In this review, the latest advances in the immune effect of RT were discussed and novel SBRT regimens were proposed, aiming to provide reference for enhancing the efficacy of radio-immunotherapy or immuno-radiotherapy in clinical practice.
