Application of MR-guided radiotherapy for brain metastases

VernacularTitle:磁共振引导自适应放疗在脑转移瘤中的应用
Author: Jingjing ZHAO ¹ ; Nan BI ; Jianping XIAO
Author Information

1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科，北京　100021
Keywords: Neoplasm metastasis, brain; Radiotherapy; Adaptive radiotherapy; MR-guided radiotherapy
From: Chinese Journal of Radiation Oncology 2023;32(1):60-64
CountryChina
Language:Chinese
Abstract: Radiotherapy (RT) is the primary local treatment modality for brain metastases, which are common secondary malignancies. Image-guidance system such as cone beam computed tomography (CBCT) may be not applicable to adaptive radiotherapy (ART), as well as hypofractionated RT in brain metastases, because it cannot clearly show the shrinkage and deformation of intracranial tumors, and the peritumoral edema changes in a real-time manner. Magnetic resonance (MR) image has high spatial resolution and soft tissue contrast and no radiation dose burden compared with CBCT. MR-guided adaptive radiotherapy (MR-gART) allows real-time tracking of deformation and position changes of the intracranial tumors, and enables online planning reconstruction during the treatment process. MR-gART could deliver high dose irradiation to the tumors while reducing the radiation dose of important organs at risk around, which contributes to achieving precision RT. In this work, the application of MR-gART in brain metastases was reviewed.