The key role of RNA N 6-methyladenosine (m 6A) methylation in tumor radiotherapy and radiation damage repair
10.3760/cma.j.cn112271-20221206-00471
- VernacularTitle:RNA m 6A甲基化修饰在肿瘤放疗和辐射损伤修复中的关键作用
- Author:
Yang FENG
1
;
Jianping CAO
;
Yang JIAO
Author Information
1. 苏州大学医学院放射医学与防护学院 放射医学与辐射防护国家重点实验室 江苏省高校放射医学协同创新中心，苏州 215123
- Keywords:
N 6-methyladenosine modification(m 6A);
m 6A methyltransferase (Writers);
m 6A demethylase (Erasers);
m 6A methyl
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(7):559-563
- CountryChina
- Language:Chinese
-
Abstract:
N 6-methyladenosine (m 6A) is the most abundant epigenetic modification in eukaryotic messenger RNA (mRNA), which could be catalyzed by m 6A methyltransferase (Writers), recognized by methylation recognition enzymes (Readers), and removed by demethylase (Erasers). RNA splicing, translation, and stability could be modulated by m 6A methylation modification. The m 6A methylation modification is involved in the biological regulation of a variety of important functional genes in cellular activities. Importantly, abnormal m 6A modification affects the occurrence, development, metastasis and recurrence of tumors. Ionizing radiation can affect the level of m 6A and m 6A methylation-related enzymes. Recently, m 6A methylation is reported to regulate the efficacy of tumor radiotherapy by affecting DNA damage and radiosensitivity of tumor cells. In addition, ionizing radiation can also affect the level of m 6A modification in normal cells to regulate the progress of radiation-induced injuries. This review summarizes the research progress on the roles of m 6A methylation in tumor radiosensitivity and radiation-induced injuries, with the aim of providing novel strategies for the development of clinical tumor radiosensitizers and radioprotective agents.
