The role and treatment strategy of epithelial-mesenchymal transition in radiation-induced pulmonary fibrosis

VernacularTitle:上皮间质转化在放射性肺纤维化中的作用及治疗策略
Author: Xingkun AO ¹ ; Ziyan YAN ; Yongqing GU
Author Information

1. 南华大学衡阳医学院　军事科学院研究生协作培养基地，衡阳　421001
Keywords: Radiation-induced pulmonary fibrosis; Epithelial-mesenchymal transition; Signal transduction; Epigenetics; Drug therapy
From: Chinese Journal of Radiological Medicine and Protection 2023;43(4):307-313
CountryChina
Language:Chinese
Abstract: Radiation-induced pulmonary fibrosis (RIPF) is one of the most serious late complications after nuclear radiation accident, bone marrow transplantation pretreatment and thoracic tumor radiotherapy. The formation process of RIPF is complicated and the pathogenesis has not been fully elucidated. Recent studies have shown that radiation-induced epithelial-mesenchymal transition (EMT) of lung epithelial cells is an indispensable segment of RIPF. This article reviews the role of radiation-induced lung EMT in the occurrence and development of RIPF and related drugs with EMT as a potential therapeutic target, providing ideas for the development of therapeutic drugs for RIPF in the future.