Research progress of the roles of metabolic reprogramming in radiation-induced direct- and bystander-effects
10.3760/cma.j.cn112271-20220628-00269
- VernacularTitle:代谢重编程在电离辐射及其旁效应中的研究进展
- Author:
Jinling WEI
1
;
Yong ZHANG
;
Xinyan PAN
;
Li WANG
Author Information
1. 昆明理工大学附属医院云南省第一人民医院病理科，昆明 650500
- Keywords:
Ionizing Radiation;
Radiation-induced bystander effect;
Metabolomics;
Metabolic reprogramming
- From:
Chinese Journal of Radiological Medicine and Protection
2023;43(2):154-160
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic reprogramming refers to the phenomenon that tumor cells, in order to meet their own growth and energy needs, regulate their biological functions by changing their metabolic mode, help themselves resist external stresses, and thus enable cells to adapt to hypoxia, acid, nutrient deficiency and other microenvironments and rapidly proliferate. It was found that metabolic reprogramming could contribute to radiation resistance and it also could be induced in bystander cells which may result in radiation resistance and the cancellation. Investigation the mechanism of radiation-induced metabolic reprogramming may provide new ideas and a theoretical framework for radiation protection, radiotherapy, and radio-diagnosis. This article reviewed the research progress on the mechanism of metabolic reprogramming in the direct and bystander effects of radiation.
