Mechanism of action of oxidative stress in severe traumatic brain injury and its complications: recent progress
10.3760/cma.j.cn501098-20230325-00162
- VernacularTitle:氧化应激在重型创伤性脑损伤及其并发症中作用机制的研究进展
- Author:
Xiaoxia WANG
1
;
Xiangming FANG
;
Jianjun LUO
;
Yong DENG
Author Information
1. 浙江大学医学院附属第一医院麻醉科，杭州 310011
- Keywords:
Brain injuries, traumatic;
Oxidative stress;
Epilepsy, post-traumatic;
Intracranial hypertension;
Brain infarction;
Peptic ulcer hemorrhage
- From:
Chinese Journal of Trauma
2023;39(6):558-569
- CountryChina
- Language:Chinese
-
Abstract:
Severe traumatic brain injury (sTBI) is characterized by critical condition, high lethality and poor prognosis. Its development and progression will lead to the damage and death of a large number of nerve cells, eventually causing a series of serious complications. The current treatments of sTBI and its complications are not optimistic due to problems such as unclear mechanism of action, challenges in treatment, and lack of effective prevention strategies. In recent years, more research evidences have shown that oxidative stress plays an important role in the development and progression of sTBI and its related complications. Therefore, it is of great significance to clarify the relationship of oxidative stress with sTBI and its complications and to understand the way of oxidative stress participating in the development and progression of sTBI. However, relevant researches are scattered and there lacks comprehensive and systematic summaries of oxidative stress participating in sTBI and its related complications. To this end, the authors reviewed the progress of the mechanism by which oxidative stress involves in sTBI and its complications, hoping to provide references for the research, treatment and prevention of sTBI.
