A case report of anti-NMDAR encephalitis complicated with acute peripheral nerve damage
10.3760/cma.j.cn101721-20230108-000010
- VernacularTitle:抗N-甲基-D-天冬氨酸受体脑炎合并急性周围神经损害1例
- Author:
Yan YANG
1
;
Xiao ZHANG
;
Xiaoyu ZHANG
;
Weiwei HUANG
;
Xiaomin LIU
;
Jiyou TANG
Author Information
1. 山东大学齐鲁医学院，济南 250012
- Keywords:
Anti-NMDAR encephalitis;
Acute peripheral nerve damage;
Critical polyneuropathy
- From:
Clinical Medicine of China
2023;39(4):272-275
- CountryChina
- Language:Chinese
-
Abstract:
N-methyl-D-aspartate receptor (NMDAR) encephalitis in combination with acute peripheral nerve damage is rare. A young female patient with anti-NMDAR encephalitis was admitted to Qianfoshan Hospital in Shandong Province on October 23, 2022. The main manifestations were abnormal mental behavior, consciousness disorders, and flaccid paralysis. Electromyography indicated axonal damage to the upper and lower extremities. Patient was in critical condition and admitted to the ICU with tracheal intubation for central hypoventilation. A combination of critical polyneuropathy was considered. The prognosis was good after hormone shock, immunosuppressive therapy, surgical therapy, anti-infection, respiratory support and symptomatic support. The diagnosis of anti-NMDAR encephalitis with acute peripheral nerve damage is difficult. Immune factors need to be considered and paraneoplastic syndrome should be differentially diagnosed.
