Research progress and clinical significance of the correlation between breast cancer heterogeneity and contrast-enhanced ultrasound
10.3760/cma.j.cn431274-20220519-00477
- VernacularTitle:乳腺癌异质性与超声造影相关性的研究进展及临床意义
- Author:
Min WEI
1
;
Guozhu WU
Author Information
1. 内蒙古医科大学内蒙古临床医学院，呼和浩特 010110
- Keywords:
Breast neoplasms;
Contrast-enhanced ultrasound;
Targeted therapy;
Biomarkers
- From:
Journal of Chinese Physician
2023;25(3):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is a highly heterogeneous tumor originating from genetic basis, with significant differences in morphology, immunophenotype and therapeutic response, which poses great challenges to the treatment of breast cancer patients. Therefore, it is very important to understand the diversity of different molecular biological states and expressions in tumor cells to obtain good therapeutic effects for breast cancer. Contrast-enhanced ultrasound (CEUS) is widely used as a non-invasive real-time diagnostic technique for breast tumors. At present, many domestic and foreign literatures have reported that there is a certain correlation between molecular biological indicators related to breast cancer and the characteristics of CEUS, which is expected to provide a reference for preoperative treatment through non-invasive and convenient ultrasound examination. The combination of ultrasound contrast agent and ultrasound can mediate the drug therapy of breast cancer, which makes the targeted delivery and targeted regulation of drugs possible, thus improving the efficiency of chemotherapy drugs. In this review, we reviewed the relationship between molecular markers related to breast cancer and CEUS and the application of ultrasound contrast agents in targeted therapy of breast cancer.
