Alterations of gut microbiota composition and cogni-tive behavior in APP/PS1/tau triple-transgenic mouse model of Alzheimer's disease
10.3867/j.issn.1000-3002.2023.07.098
- Author:
Wei ZHANG
1
;
Jingshan SHI
Author Information
1. Key Laboratory of Basic Pharmacology of Ministry of Edu-cation and Joint International Research Laboratory of Ethno-medicine of Ministry of Education,Zunyi Medical University,Zunyi 563003,China
- Keywords:
Alzheimer disease;
triple-transgenic mice;
amyloid β-protein accumulation;
metabolic dysfunction;
gut microbiota dysbiosis
- From:
Chinese Journal of Pharmacology and Toxicology
2023;37(7):521-521
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Alzheimer's disease(AD)is a progressive neurological disease.Given the important role of gut microbiota composition in AD pathology,the observed perturbation in the microbiota composition and diversity may serve as the mechanisms underlying age-dependent APP/PS1/tau triple-transgenic mouse(3×Tg-AD)mice amyloid deposition and memory deficits.Here-in,we intended to investigate the gut microbiota and as-sessed its relationship with the triggering and develop-ment of cognitive impairment of AD.METHODS This study involves the comparative assessment of spatial learning,amyloid β-protein(Aβ)accumulation,and fecal microbiota alterations in 3×Tg-AD mice from three age groups:AD asymptomatic stage(3 m),presymptomatic stage(6 m),and the symptomatic stage of AD(9 m).RE-SULTS We demonstrate that spatial memory deficits,brain Aβ accumulation,and weight gain in 3×Tg-AD mice gradually appear after 6 months of age.However,the total gut bacterial counts underwent changes from 3 to 6 months of age and were further altered at 9 months of age.Importantly,changes in gut bacteria abundance of Desulfobacterota and Actinobacteriota phylain 6-month-old mice preceded apparent spatial memory deficits.CONCLUSION Changes in the gut microbial community are one of the mechanisms of early AD pathology.
