Epigenetic mechanism of myopia

VernacularTitle:近视的表观遗传学机制
Author: Wei GONG ¹ ; Kun LIU ; Xiangui HE
Author Information

1. 上海市眼病防治中心　上海市眼科医院/上海市视觉健康中心，上海　200050
Keywords: Myopia; Epigenetics; DNA methylation; Non-coding RNA; Histone modification
From: Chinese Journal of Experimental Ophthalmology 2023;41(9):939-943
CountryChina
Language:Chinese
Abstract: Myopia has become a serious public health problem, but its pathogenesis is still unclear, and effective interventions are relatively scarce.It is recognized that myopia is influenced by both genetic and environmental factors, in which epigenetics may play a key role.Epigenetics refers to the changes in gene expression and function that do not involve DNA sequence variation.Mainly including DNA methylation, non-coding RNA (microRNA, long non-coding RNA and circular RNA, etc.), histone modification and mRNA modification, epigenetic modifications interact to form a complex regulatory network in the pathophysiological process of myopia.By controlling the process of scleral matrix remodeling, eye cell proliferation and retinal development, the morphological characteristics of the eye are jointly regulated, ultimately affecting the onset and development of myopia.Epigenetics has provided new targets of myopia intervention and has become a hotspot in the field.In this paper, we reviewed the current findings of myopia epigenetics to provide a reference for related research.