Research advances in neuroprotective role of sigma-1 receptor in retina
10.3760/cma.j.cn115989-20200110-00017
- VernacularTitle:Sigma-1受体介导的视网膜神经保护作用研究进展
- Author:
Xiaochen MA
1
;
Hongling LIU
Author Information
1. 哈尔滨医科大学第一附属医院眼科医院，哈尔滨 150000
- Keywords:
Retina;
Sigma-1 receptor;
Nerve protection
- From:
Chinese Journal of Experimental Ophthalmology
2023;41(5):512-515
- CountryChina
- Language:Chinese
-
Abstract:
Retinal degenerative diseases are a major contributor to visual impairment worldwide, and research related to retinal degenerative diseases is increasingly becoming a hot topic.The sigma-1 receptor is a 223-amino-acid endoplasmic reticulum transmembrane protein, and its gene sequence is highly conserved throughout mammals.Sigma-1 receptors are widely distributed in various tissues and organs.Numerous studies have proved the protective role of sigma-1 receptors in retinal pathological processes, including anti-oxidative stress, anti-inflammatory response, and anti-apoptosis.In addition, sigma-1 receptors have potential therapeutic roles in retinal diseases, especially diabetic retinopathy, retinitis pigmentosa and glaucomatous neuropathy.In this paper, the molecular mechanisms of sigma-1 receptor-mediated retinal neuroprotection and its application in the treatment of retinal diseases were reviewed.
