Risk factors of hydrocephalus secondary to severe intraventricular hemorrhage in preterm infants
10.3760/cma.j.issn.2096-2932.2023.07.004
- VernacularTitle:早产儿严重脑室内出血继发脑积水危险因素分析
- Author:
Guanchu CHEN
1
;
Hongxia GAO
;
Ting YANG
;
Xiao TAN
;
Bin YI
;
Jianming TANG
Author Information
1. 甘肃省妇幼保健院，甘肃省中心医院，甘肃省儿童医学中心新生儿科，兰州 730050
- Keywords:
Intraventricular hemorrhage;
Hydrocephalus;
Premature infant;
Risk factors
- From:Chinese Journal of Neonatology
2023;38(7):407-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors of secondary hydrocephalus after severe intraventricular hemorrhage (IVH) in preterm infants for prevention and early identification of post-hemorrhagic hydrocephalus (PHH).Methods:From June 2013 to June 2021, preterm infants with severe IVH admitted to our hospital were retrospectively analyzed. They were assigned into PHH group and non-PHH group. Rank sum test or chi-square test was used for comparison between the two groups and multivariate logistic regression analysis was used to analyze the risk factors of PHH in preterm infants.Results:A total of 246 preterm infants with severe IVH were enrolled, including 68 cases (27.6%) in the PHH group and 178 cases (72.4%) in the non-PHH group. Multivariate logistic stepwise regression analysis showed that male gender ( OR=2.014, 95% CI 1.063-3.817), gestational age ≤30 week ( OR=2.240, 95% CI 1.210-4.146), 5-min Apgar score ≤5 ( OR=3.980, 95% CI 1.483-10.685), placental abruption ( OR=2.940, 95% CI 1.324-6.531) were independent risk factors for PHH in preterm infants and thrombocytopenia was the protective factor for PHH in preterm infants ( OR=0.305, 95% CI 0.147-0.632). The incidence of moderate thrombocytopenia in non-PHH group was significantly higher than PHH group ( P<0.05). No significant differences existed in the incidences of mild and severe thrombocytopenia between the two groups ( P>0.05). Conclusions:Male gender, gestational age ≤30 week, 5-min Apgar score ≤5, placental abruption are risk factors for PHH in premature infants with severe IVH and moderate thrombocytopenia has protective effects.
