Risk factors for retinopathy of prematurity in very low birth weight infants
10.3760/cma.j.issn.2096-2932.2023.06.006
- VernacularTitle:极低出生体重儿发生早产儿视网膜病的危险因素分析
- Author:
Guanchu CHEN
1
;
Ting YANG
;
Jianming TANG
;
Xiao TAN
;
Bin YI
;
Hongxia GAO
Author Information
1. 甘肃省妇幼保健院，甘肃省中心医院，甘肃省儿童医学中心新生儿科，兰州 730050
- Keywords:
Hyperglycemia;
Retinopathy of prematurity;
Very low birth weight infant;
Premature infant
- From:Chinese Journal of Neonatology
2023;38(6):349-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the risk factors for retinopathy of prematurity (ROP) in very low birth weight infants (VLBWIs).Methods:From October 2020 to December 2021, VLBWIs with gestational age(GA) ≤32 weeks admitted to the neonatal department of our hospital were retrospectively studied. According to the occurrence of ROP, they were assigned into ROP group and non-ROP group. The clinical data of the two groups were compared and the risk factors of ROP in VLBWI were analyzed.Results:A total of 251 VLBWIs were enrolled, including 60 cases (23.9%) in ROP group and 191 (76.1%) in non-ROP group. The GA and birth weight (BW) of ROP group were significantly lower than non-ROP group [28(26,30) w vs. 29(28,31) w, 1 035(840,1 285) g vs. 1 260(1 110,1 380) g, respectively, all P<0.001]. The ROP group had longer duration of oxygen therapy [42.0(26.0, 53.5) d vs. 24.0(18.0, 34.0) d], higher incidences of blood transfusion [2.5(1.0, 3.0) times vs. 2.0 (1.0, 2.0) times] and hyperglycemia (80.0% vs. 16.8%), higher average [(5.6±0.5) mmol/L vs. (5.1±0.5) mmol/L] and peak [10.4(7.8,13.2) mmol/L vs. 6.5(6.1,6.8) mmol/L] blood glucose levels in the first week than the non-ROP group (all P<0.001). Multivariate analysis showed that longer duration of oxygen therapy ( OR=1.047, 95% CI 1.008-1.087, P=0.018) and higher peak blood glucose level in the first week ( OR=1.268, 95% CI 1.092-1.474, P=0.002) were the independent risk factors for ROP. Conclusions:Longer duration of oxygen therapy and higher peak of blood glucose level in the first week are risk factors for ROP in VLBWIs.
