Prognosis analysis and strategies selection in liver transplantation for intrahepatic cholangio-carcinoma
10.3760/cma.j.cn115610-20221123-00707
- VernacularTitle:肝内胆管细胞癌肝移植治疗的预后分析与策略选择
- Author:
Guoyue LYU
1
;
Dawei SUN
Author Information
1. 吉林大学第一医院普通外科中心肝胆胰外一科，长春 130021
- Keywords:
Liver neoplasms;
Liver transplantation;
Prognosis;
Tumor burden;
Tumor biological behavior;
Neoadjuvant therapy
- From:
Chinese Journal of Digestive Surgery
2023;22(2):187-194
- CountryChina
- Language:Chinese
-
Abstract:
Intrahepatic cholangiocarcinoma (ICC) is a complex malignant tumor with poor prognosis. Historically, the prognosis of ICC patients after liver transplantation is poor, which led to that it is once regarded as a contraindication of liver transplantation. However, in recent years, results of multiple studies challenge the above view. These emerging studies demonstrate that under the condition of reasonable selection of recipients or combined with neoadjuvant therapy, liver trans-plantation has achieved considerable prognosis in patients with ICC. In addition, compared with surgical resection and other treatments, liver transplantation can improve the prognosis of patients with ICC. The factors related to the prognosis of ICC patients who underwent liver transplantation include neoadjuvant therapy, overall tumor burden, tumor biological behavior and comprehensive treatment after transplantation, et al. Based on the results from currently existing clinical studies, the authors make a deep elaboration on the prognosis of ICC patients after liver transplantation, prognosis comparison between liver transplantation and other treatment measures for ICC, factors related to the prognosis of ICC patients who underwent liver transplantation, and the selection strategy of recipient of liver transplantation for ICC, and advance and challenge of liver transplantation for ICC.
