Intestinal microecology and sepsis
10.3760/cma.j.issn.1673-4912.2023.02.002
- VernacularTitle:肠道微生态与脓毒症
- Author:
Zihao YANG
1
;
Chenmei ZHANG
Author Information
1. 浙江大学医学院附属儿童医院PICU 国家儿童健康与疾病临床研究中心，杭州 310056
- Keywords:
Sepsis;
Intestinal microecology;
Intestinal flora;
Children
- From:
Chinese Pediatric Emergency Medicine
2023;30(2):85-89
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a common critical illness in PICU, with high morbidity and mortality.As the pathogenesis is still not well defined, the clinical management of sepsis can be tricky.The gastrointestinal tract is currently considered as one of the most susceptible organs in the early stages of sepsis, and intestinal microecology plays important roles in the development, progression and prognosis of this disease.There is a closely relationship between intestinal flora dysbiosis/translocation and sepsis.They interact with each other, and ultimately leading to multi-organ dysfunction.In this review, we provided a brief summary of intestinal microecological changes and its pathogenesis in sepsis, as well as the progress of treatment.
