Novel biomarkers of sepsis-associated acute respiratory distress syndrome
10.3760/cma.j.issn.1673-4912.2022.12.004
- VernacularTitle:脓毒症相关急性呼吸窘迫综合征新型生物学标志物
- Author:
Chunxia WANG
1
;
Xi XIONG
;
Yucai ZHANG
Author Information
1. 上海市儿童医院 上海交通大学医学院附属儿童医院重症医学科 200062
- Keywords:
Gene expression signature;
Multiple omics analysis;
Biomarkers;
Molecular subtype;
Sepsis;
Acute respiratory distress syndrome
- From:
Chinese Pediatric Emergency Medicine
2022;29(12):957-962
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome(ARDS)is one of the most common complications of sepsis, resulting in the high risk of death in patients with sepsis.By comparison with non-septic ARDS, sepsis-associated ARDS is characterized by high morbidity, heterogeneity and mortality.It is vital to early identify the occurrence of ARDS, accurately assess the severity, as well as effectively implement the individualized treatment.Based on the genome-wide association study, mass cytometry, and multiple omics data analysis, the molecular signatures of sepsis-associated ARDS have been elucidated, which were related to genetic susceptibility, inflammatory reaction pathway, and metabolic characteristics.The development of novel biomarkers is helpful to molecular classifier, risk stratification, early recognition and assessing severity, implement early intervention, then improving the prognosis.
