Advances in kidney transplantation for children with hereditary nephrotic syndrome
10.3760/cma.j.cn101070-20220616-00724
- VernacularTitle:儿童遗传性肾病综合征肾移植治疗相关进展
- Author:
Yi FENG
1
;
Yonghua FENG
;
Wenjun SHANG
Author Information
1. 郑州大学第一附属医院肾移植科，郑州 450052
- Keywords:
Hereditary;
Nephrotic syndrome;
Kidney transplantation;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(9):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Hereditary nephrotic syndrome (NS) has a high risk of progression to end-stage renal disease.Renal transplantation is the optimal renal replacement therapy.The specificity of hereditary NS in the field of kidney transplantation has not been systematically illustrated yet.Due to the large amount of hormone uses before operation, the difference of immunosuppressive therapy in patients with hereditary NS should be well concerned, including the selection of immune induction and maintenance regimens.Relatives of patients with hereditary NS should undergo genetic testing before living donor transplantation, and donors are qualified only after a thorough risk assessment and informed consent.Post-transplant recurrence of hereditary NS is rare, with an acceptable response to plasma exchange.This review aims to describe the characteristics of hereditary NS in children in the field of kidney transplantation, thus providing guidance for kidney transplantation for hereditary NS.
