Immune debt and its impact in children during severe acute respiratory syndrome coronavirus 2 epidemic
10.3760/cma.j.cn101070-20230104-00004
- VernacularTitle:儿童新型冠状病毒流行期间的免疫债及其影响
- Author:
Peng HAN
1
;
Yuejie ZHENG
;
Yonghong YANG
;
Kunling SHEN
Author Information
1. 国家儿童医学中心，国家呼吸系统疾病临床医学研究中心，首都医科大学附属北京儿童医院呼吸科，北京 100045
- Keywords:
Severe acute respiratory syndrome coronavirus 2;
Non-pharmaceutical intervention;
Immune debt;
Child
- From:
Chinese Journal of Applied Clinical Pediatrics
2023;38(1):4-9
- CountryChina
- Language:Chinese
-
Abstract:
Non-pharmaceutical interventions (NPIs) implemented during the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) epidemic have been proven to be effective in blocking the spread of the epidemic.While reducing SARS-CoV-2 transmission, NPIs also reduce children exposure to other pathogens, leading to a decline in the incidence of many viral and bacterial infections.The reduction in contact with viruses and bacteria and the delay or interruption of routine immunization during SARS-CoV-2 epidemic have resulted in insufficient immune stimulation of pathogens on the population, leading to an increase in susceptible populations and a decline in herd immunity, forming the immune debt during SARS-CoV-2 epidemic.After reducing or lifting NPIs, the incidence of some viral or bacterial infectious diseases was significantly higher than pre-epidemic.In this review, the definition, source, impact and strategies of immune debt during epidemic period were expounded, inorder to improve clinicians′ attention and understanding of immune debt and optimize the prevention of children′s infectious diseases.
