Research progress of heat shock protein 90 in breast cancer
10.3760/cma.j.cn.115807-20220811-00220
- VernacularTitle:热休克蛋白90在乳腺癌中的临床研究进展
- Author:
Maolin GUO
1
;
Chao ZHENG
;
Lixiang YU
;
Liyuan LIU
;
Linfeng ZHAO
;
Zhigang YU
Author Information
1. 山东大学第二医院乳腺外科，山东大学乳腺疾病防治转化医学研究所，山东省乳腺疾病防治转化工程实验室，济南 250033
- Keywords:
Heat shock protein 90;
Breast cancer;
Clinicopathologic feature;
Prognosis;
Inhibitors
- From:
Chinese Journal of Endocrine Surgery
2023;17(2):249-252
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer has become the most common malignant tumor in the world. Heat shock protein 90 (HSP90) is a kind of molecular chaperone which can promote protein folding and maintain protein stability. HSP90 includes HSP90α, HSP90β, GRP94 and TRAP1 subtypes. Previous studies have found that the level of HSP90 is significantly increased in malignant tumors such as breast cancer, and is closely related to the occurrence and development of tumors. Meanwhile, the research on inhibitors targeting HSP90 has also attracted much attention. In this paper, we reviewed the expression of four HSP90 subtypes in breast cancer and their relationship with the clinicopathologic feature and prognosis of patients, discussed the research progress of specific inhibitors of HSP90 subtypes in breast cancer, and analyzed the application prospect of HSP90 as biomarkers for breast cancer prognosis monitoring and therapeutic targets.
