Effect of ulinastatin injection on left ventricular diastolic function in patients with sepsis
10.3760/cma.j.issn.1671-0282.2023.06.010
- VernacularTitle:乌司他丁注射液对脓毒症患者左心室舒张功能的影响
- Author:
Sheng LU
1
;
Jie SHAO
;
Sheng YU
;
Jianfeng ZHANG
;
Jun SHA
;
Yufeng FENG
Author Information
1. 常熟市第二人民医院（扬州大学第五临床医学院）重症医学科，苏州 215500
- Keywords:
Sepsis;
Left ventricular diastolic function;
Cardiac dysfunction;
Ulinastatin injection;
Inflammatory response
- From:
Chinese Journal of Emergency Medicine
2023;32(6):775-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of ulinastatin injection on left ventricular diastolic function and prognosis in patients with sepsis.Methods:A total of 100 patients with sepsis admitted to the Intensive Care Unit from January 2021 to March 2022 were selected. According to the random number table, they were randomly (random number) divided into the control group (conventional treatment) and experimental group (conventional treatment + ulinastatin injection). The baseline data on admission were compared between the two groups. The echocardiographic indexes [mitral peak velocity of early filling/early diastolic mitral annular velocity (E/e'), early diastolic mitral annular velocity (e'), mitral peak velocity of early filling/ mitral peak velocity of late filling (E/A), and tricuspid regurgitation rate (TRV)], myocardial damage-related and cardiac function-related indicators [troponin I (cTnI), N terminal pro B type natriuretic peptide (NTproBNP)] and inflammation-related indicators [C-reaction protein (CRP), procalcitonin (PCT), erythrocyte sedimentation rate (ESR)], length of ICU stay, duration of infection control, duration of vasoactive drug use and 28-day mortality were observed and compared between the two groups on admission and 7 days after treatment.Results:On the 7th day after treatment, the levels of e 'and E/A in the experimental group were significantly higher than those in the control group, and the levels of E/e', TRV, cTnI, NTproBNP, CRP and PCT were significantly decreased ( P<0.05). There were no significant differences in duration of infection control and duration of vasoactive drug use between the experimental group and the control group ( P<0.05), but the length of ICU stay was shorter and 28-day mortality was significantly lower in the experimental group than in the control group ( P<0.05). Conclusions:Ulinastatin can reduce the degree of inflammatory response, relieve myocardial injury, improve left ventricular diastolic function, and reduce the length of ICU stay and 28-day mortality in patients with sepsis.
