Research progress in the theoretical connotation and mechanism of the eliminating dampness-heat method for the treatment of chronic kidney disease
10.3760/cma.j.cn115398-20220104-00022
- VernacularTitle:清利湿热法治疗慢性肾脏病理论内涵及研究进展
- Author:
Min LIU
1
;
Chunbo JIANG
Author Information
1. 南京中医药大学2020级硕士研究生，南京 210023
- Keywords:
Therapeutic methods (TCMP);
Eliminating dampness-heat method;
Chronic kidney disease;
Immune inflammation;
Oxidative stress;
Renal fibrosis
- From:
International Journal of Traditional Chinese Medicine
2023;45(1):113-116
- CountryChina
- Language:Chinese
-
Abstract:
This article aimed to explore the theoretical connotation and mechanism of clearing damp-heat method in the treatment of chronic kidney disease (CKD), provide theoretical support for clearing damp-heat method in the treatment of chronic kidney disease, and further explain the modern scientific connotation of "damp-heat impairing kidney". Modern Traditional Chinese Medicine (TCM) believes that damp-heat is an important pathogenesis of kidney damage. Clearing damp-heat method plays a key role in inhibiting CKD immune inflammatory response, improving oxidative stress and antagonizing renal fibrosis. The mechanism is mainly related to the regulation of TNF-α level, blocking NF-κB signaling pathway, inhibiting inflammatory cytokines, antagonizing TGF-β1 secretion and other pathways.
