Research progress of cancer-associated fibroblasts in tumor radiotherapy resistance
10.3760/cma.j.cn371439-20230105-00044
- VernacularTitle:癌相关成纤维细胞在肿瘤放疗抵抗中的研究进展
- Author:
Meng XU
1
;
Wei JIANG
;
Haitao ZHU
;
Xiongfeng CAO
Author Information
1. 江苏大学附属医院放射科，镇江 212001
- Keywords:
Neoplasms;
Radiotherapy;
Cancer-associated fibroblast;
Tumor microenvironment
- From:
Journal of International Oncology
2023;50(4):227-230
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts (CAFs) is considered as a key factor for the severely limited efficacy in tumor radiotherapy. CAFs, as the primary stromal cells in the tumor microenvironment, can lead to tumor radiotherapy resistance by secreting a series of pro-tumor cytokines and nutrients, inhibiting anti-tumor immune response and remodeling extracellular matrix. Some progress has been made in the study of targeted CAFs sensitization radiotherapy, but the relevant study system is still imperfect. Therefore, a systematic exploration of the role of CAFs in tumor radiotherapy resistance and CAFs targeted therapy strategies can provide a basis for improving the current status of tumor radiotherapy resistance.
