Research progress of primary pulmonary lymphoepithelioma-like carcinoma

VernacularTitle:原发性肺淋巴上皮瘤样癌的研究进展
Author: Pengcheng MA ¹ ; Yu CHEN
Author Information

1. 中国医科大学附属盛京医院呼吸与危重症医学科，沈阳　110004
Keywords: Herpesvirus 4, human; Immunotherapy; Pulmonary lymphoepithelioma-like carcinoma
From: Journal of International Oncology 2023;50(3):174-178
CountryChina
Language:Chinese
Abstract: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a distinct type of lung cancer with histological profiles similar to nasopharyngeal carcinoma. The development is associated with EBV and plasma EBV DNA has predictive value in the progression and prognosis of PPLELC. PPLELC is different from some other types of lung cancer in that it has a low mutation rate of the classical lung cancer driver genes and targeted therapy is ineffective for it. Chemotherapy combined with immunotherapy may be the best first-line treatment option for patients with advanced PPLELC.